Investigating Osteocytic Perilacunar/Canalicular Remodeling
Purpose of Review In perilacunar/canalicular remodeling (PLR), osteocytes dynamically resorb, and then replace, the organic and mineral components of the pericellular extracellular matrix. Given the enormous surface area of the osteocyte lacuna-canalicular network (LCN), PLR is important for maintai...
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| Veröffentlicht in: | Current osteoporosis reports 2019-08, Vol.17 (4), p.157-168 |
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| creator | Yee, Cristal S. Schurman, Charles A. White, Carter R. Alliston, Tamara |
| description | Purpose of Review
In perilacunar/canalicular remodeling (PLR), osteocytes dynamically resorb, and then replace, the organic and mineral components of the pericellular extracellular matrix. Given the enormous surface area of the osteocyte lacuna-canalicular network (LCN), PLR is important for maintaining homeostasis of the skeleton. The goal of this review is to examine the motivations and critical considerations for the analysis of PLR, in both in vitro and in vivo systems.
Recent Findings
Morphological approaches alone are insufficient to elucidate the complex mechanisms regulating PLR in the healthy skeleton and in disease. Understanding the role and regulation of PLR will require the incorporation of standardized PLR outcomes as a routine part of skeletal phenotyping, as well as the development of improved molecular and cellular outcomes. Current PLR outcomes assess PLR enzyme expression, the LCN, and bone matrix composition and organization, among others.
Summary
Here, we discuss current PLR outcomes and how they have been applied to study PLR induction and suppression in vitro and in vivo
.
Given the role of PLR in skeletal health and disease, integrated analysis of PLR has potential to elucidate new mechanisms by which osteocytes participate in skeletal health and disease. |
| doi_str_mv | 10.1007/s11914-019-00514-0 |
| format | Article |
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In perilacunar/canalicular remodeling (PLR), osteocytes dynamically resorb, and then replace, the organic and mineral components of the pericellular extracellular matrix. Given the enormous surface area of the osteocyte lacuna-canalicular network (LCN), PLR is important for maintaining homeostasis of the skeleton. The goal of this review is to examine the motivations and critical considerations for the analysis of PLR, in both in vitro and in vivo systems.
Recent Findings
Morphological approaches alone are insufficient to elucidate the complex mechanisms regulating PLR in the healthy skeleton and in disease. Understanding the role and regulation of PLR will require the incorporation of standardized PLR outcomes as a routine part of skeletal phenotyping, as well as the development of improved molecular and cellular outcomes. Current PLR outcomes assess PLR enzyme expression, the LCN, and bone matrix composition and organization, among others.
Summary
Here, we discuss current PLR outcomes and how they have been applied to study PLR induction and suppression in vitro and in vivo
.
Given the role of PLR in skeletal health and disease, integrated analysis of PLR has potential to elucidate new mechanisms by which osteocytes participate in skeletal health and disease.</description><identifier>ISSN: 1544-1873</identifier><identifier>EISSN: 1544-2241</identifier><identifier>DOI: 10.1007/s11914-019-00514-0</identifier><identifier>PMID: 31227998</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Bone Matrix - metabolism ; Bone Matrix - ultrastructure ; Bone Remodeling - physiology ; Carbonic Anhydrases - metabolism ; Cathepsin K - metabolism ; Cell Line ; Epidemiology ; Homeostasis ; Humans ; Hydrogen-Ion Concentration ; Imaging, Three-Dimensional ; Matrix Metalloproteinases - metabolism ; Medicine ; Medicine & Public Health ; Microscopy, Confocal ; Microscopy, Electron, Scanning ; Orthopedics ; Osteocytes - enzymology ; Osteocytes - metabolism ; Osteocytes - ultrastructure ; Proton-Translocating ATPases - metabolism ; Section Editors ; Skeletal Biology and Regulation (M Forwood and A Robling ; Topical Collection on Skeletal Biology and Regulation ; X-Ray Microtomography</subject><ispartof>Current osteoporosis reports, 2019-08, Vol.17 (4), p.157-168</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-44e4c08bd8eed5feba4569bbf507d82abebe18ba3d8308f52ed241108a7b66ae3</citedby><cites>FETCH-LOGICAL-c446t-44e4c08bd8eed5feba4569bbf507d82abebe18ba3d8308f52ed241108a7b66ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11914-019-00514-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11914-019-00514-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31227998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yee, Cristal S.</creatorcontrib><creatorcontrib>Schurman, Charles A.</creatorcontrib><creatorcontrib>White, Carter R.</creatorcontrib><creatorcontrib>Alliston, Tamara</creatorcontrib><title>Investigating Osteocytic Perilacunar/Canalicular Remodeling</title><title>Current osteoporosis reports</title><addtitle>Curr Osteoporos Rep</addtitle><addtitle>Curr Osteoporos Rep</addtitle><description>Purpose of Review
In perilacunar/canalicular remodeling (PLR), osteocytes dynamically resorb, and then replace, the organic and mineral components of the pericellular extracellular matrix. Given the enormous surface area of the osteocyte lacuna-canalicular network (LCN), PLR is important for maintaining homeostasis of the skeleton. The goal of this review is to examine the motivations and critical considerations for the analysis of PLR, in both in vitro and in vivo systems.
Recent Findings
Morphological approaches alone are insufficient to elucidate the complex mechanisms regulating PLR in the healthy skeleton and in disease. Understanding the role and regulation of PLR will require the incorporation of standardized PLR outcomes as a routine part of skeletal phenotyping, as well as the development of improved molecular and cellular outcomes. Current PLR outcomes assess PLR enzyme expression, the LCN, and bone matrix composition and organization, among others.
Summary
Here, we discuss current PLR outcomes and how they have been applied to study PLR induction and suppression in vitro and in vivo
.
Given the role of PLR in skeletal health and disease, integrated analysis of PLR has potential to elucidate new mechanisms by which osteocytes participate in skeletal health and disease.</description><subject>Bone Matrix - metabolism</subject><subject>Bone Matrix - ultrastructure</subject><subject>Bone Remodeling - physiology</subject><subject>Carbonic Anhydrases - metabolism</subject><subject>Cathepsin K - metabolism</subject><subject>Cell Line</subject><subject>Epidemiology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Imaging, Three-Dimensional</subject><subject>Matrix Metalloproteinases - metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microscopy, Confocal</subject><subject>Microscopy, Electron, Scanning</subject><subject>Orthopedics</subject><subject>Osteocytes - enzymology</subject><subject>Osteocytes - metabolism</subject><subject>Osteocytes - ultrastructure</subject><subject>Proton-Translocating ATPases - metabolism</subject><subject>Section Editors</subject><subject>Skeletal Biology and Regulation (M Forwood and A Robling</subject><subject>Topical Collection on Skeletal Biology and Regulation</subject><subject>X-Ray Microtomography</subject><issn>1544-1873</issn><issn>1544-2241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMobk7_gBeyS2_qkjRpUwRBhh-DwUT0OiTpac3o2pm0g_17MzuH3niVA-c5b855ELok-IZgnE48IRlhESZZhDHfVUdoSDhjEaWMHO9rItJ4gM68X2JMKWHxKRrEhNI0y8QQ3c7qDfjWlqq1dTle-BYas22tGb-As5UyXa3cZKpqVVnTVcqNX2HV5FAF-hydFKrycLF_R-j98eFt-hzNF0-z6f08MowlbcQYMIOFzgVAzgvQivEk07rgOM0FVRo0EKFVnIsYi4JTyMP6BAuV6iRREI_QXZ-77vQKcgN161Ql186ulNvKRln5t1PbD1k2G5lSTOMsDQHX-wDXfHbhXLmy3kBVqRqazsugiyeM82SH0h41rvHeQXH4hmC5sy576zJYl9_WJQ5DV78XPIz8aA5A3AM-tOoSnFw2nQtO_X-xXwL9j6g</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Yee, Cristal S.</creator><creator>Schurman, Charles A.</creator><creator>White, Carter R.</creator><creator>Alliston, Tamara</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190801</creationdate><title>Investigating Osteocytic Perilacunar/Canalicular Remodeling</title><author>Yee, Cristal S. ; Schurman, Charles A. ; White, Carter R. ; Alliston, Tamara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-44e4c08bd8eed5feba4569bbf507d82abebe18ba3d8308f52ed241108a7b66ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bone Matrix - metabolism</topic><topic>Bone Matrix - ultrastructure</topic><topic>Bone Remodeling - physiology</topic><topic>Carbonic Anhydrases - metabolism</topic><topic>Cathepsin K - metabolism</topic><topic>Cell Line</topic><topic>Epidemiology</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Imaging, Three-Dimensional</topic><topic>Matrix Metalloproteinases - metabolism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microscopy, Confocal</topic><topic>Microscopy, Electron, Scanning</topic><topic>Orthopedics</topic><topic>Osteocytes - enzymology</topic><topic>Osteocytes - metabolism</topic><topic>Osteocytes - ultrastructure</topic><topic>Proton-Translocating ATPases - metabolism</topic><topic>Section Editors</topic><topic>Skeletal Biology and Regulation (M Forwood and A Robling</topic><topic>Topical Collection on Skeletal Biology and Regulation</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yee, Cristal S.</creatorcontrib><creatorcontrib>Schurman, Charles A.</creatorcontrib><creatorcontrib>White, Carter R.</creatorcontrib><creatorcontrib>Alliston, Tamara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current osteoporosis reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yee, Cristal S.</au><au>Schurman, Charles A.</au><au>White, Carter R.</au><au>Alliston, Tamara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigating Osteocytic Perilacunar/Canalicular Remodeling</atitle><jtitle>Current osteoporosis reports</jtitle><stitle>Curr Osteoporos Rep</stitle><addtitle>Curr Osteoporos Rep</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>17</volume><issue>4</issue><spage>157</spage><epage>168</epage><pages>157-168</pages><issn>1544-1873</issn><eissn>1544-2241</eissn><abstract>Purpose of Review
In perilacunar/canalicular remodeling (PLR), osteocytes dynamically resorb, and then replace, the organic and mineral components of the pericellular extracellular matrix. Given the enormous surface area of the osteocyte lacuna-canalicular network (LCN), PLR is important for maintaining homeostasis of the skeleton. The goal of this review is to examine the motivations and critical considerations for the analysis of PLR, in both in vitro and in vivo systems.
Recent Findings
Morphological approaches alone are insufficient to elucidate the complex mechanisms regulating PLR in the healthy skeleton and in disease. Understanding the role and regulation of PLR will require the incorporation of standardized PLR outcomes as a routine part of skeletal phenotyping, as well as the development of improved molecular and cellular outcomes. Current PLR outcomes assess PLR enzyme expression, the LCN, and bone matrix composition and organization, among others.
Summary
Here, we discuss current PLR outcomes and how they have been applied to study PLR induction and suppression in vitro and in vivo
.
Given the role of PLR in skeletal health and disease, integrated analysis of PLR has potential to elucidate new mechanisms by which osteocytes participate in skeletal health and disease.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31227998</pmid><doi>10.1007/s11914-019-00514-0</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Bone Matrix - metabolism Bone Matrix - ultrastructure Bone Remodeling - physiology Carbonic Anhydrases - metabolism Cathepsin K - metabolism Cell Line Epidemiology Homeostasis Humans Hydrogen-Ion Concentration Imaging, Three-Dimensional Matrix Metalloproteinases - metabolism Medicine Medicine & Public Health Microscopy, Confocal Microscopy, Electron, Scanning Orthopedics Osteocytes - enzymology Osteocytes - metabolism Osteocytes - ultrastructure Proton-Translocating ATPases - metabolism Section Editors Skeletal Biology and Regulation (M Forwood and A Robling Topical Collection on Skeletal Biology and Regulation X-Ray Microtomography |
| title | Investigating Osteocytic Perilacunar/Canalicular Remodeling |
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