Wip1 regulates Smad4 phosphorylation and inhibits TGF‐β signaling

The tumor suppressor Smad4, a key mediator of the TGF‐β/BMP pathways, is essential for development and tissue homeostasis. Phosphorylation of Smad4 in its linker region catalyzed by the mitogen‐activated protein kinase (MAPK) plays a pivotal role in regulating its transcriptional activity and stabil...

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Veröffentlicht in:	EMBO reports 2020-05, Vol.21 (5), p.e48693-n/a
Hauptverfasser:	Park, Dong‐Seok, Yoon, Gang‐Ho, Kim, Eun‐Young, Lee, Taehyeong, Kim, Kyuhee, Lee, Peter CW, Chang, Eun‐Ju, Choi, Sun‐Cheol
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Animals Cancer Control stability Dephosphorylation EMBO11 EMBO31 EMBO37 Embryos Homeostasis Humans Kinases MAP kinase Mesoderm Mitogen-Activated Protein Kinases - metabolism phosphatase Phosphorylation Protein kinase Protein Phosphatase 2C - genetics Protein Phosphatase 2C - metabolism Regulatory mechanisms (biology) Signal Transduction Signaling Smad4 Smad4 protein Smad4 Protein - genetics Smad4 Protein - metabolism TGF‐β Transcription Transforming Growth Factor beta - metabolism Transforming growth factor-b Tumor suppressor genes Tumorigenicity Wip1 Xenopus Xenopus laevis - metabolism Xenopus Proteins - genetics Xenopus Proteins - metabolism
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