A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans

T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine fetal thymus by day 16 of ontogeny, underwent αβ TCR-mediated positive selecti...

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Veröffentlicht in:	The Journal of experimental medicine 2020-05, Vol.217 (5)
Hauptverfasser:	Edwards, Sarah C, Sutton, Caroline E, Ladell, Kristin, Grant, Emma J, McLaren, James E, Roche, Fiona, Dash, Pradyot, Apiwattanakul, Nopporn, Awad, Walid, Miners, Kelly L, Lalor, Stephen J, Ribot, Julie C, Baik, Song, Moran, Barry, McGinley, Aoife, Pivorunas, Valerie, Dowding, Lori, Macoritto, Michael, Paez-Cortez, Jesus, Slavin, Anthony, Anderson, Graham, Silva-Santos, Bruno, Hokamp, Karsten, Price, David A, Thomas, Paul G, McLoughlin, Rachel M, Mills, Kingston H G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmunity Biomarkers - metabolism Brief Definitive Report Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Humans Inflammation - immunology Inflammation - pathology Lymphocyte Activation - immunology Mice, Inbred C57BL Neuroinflammation Phenotype Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - metabolism Receptors, Antigen, T-Cell, gamma-delta - genetics Receptors, Antigen, T-Cell, gamma-delta - metabolism Staphylococcal Infections - immunology Staphylococcus aureus - physiology T-Lymphocytes - immunology Transcription, Genetic Transcriptome - genetics
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