Quadrella incana (Capparaceae) Leaf Extract Enhances Proliferation and Maintenance of Neural Stem/Progenitor Cells through Upregulating Glycolytic Flux and Redox Potential
Neural stem/progenitor cells (NSPCs) are self-renewing, multipotent cells located in the embryonic and adult central nervous system (CNS). Extensive preclinical and clinical studies have shed light on the potential of stem cell replacement therapy for various neurodegenerative diseases. The key prer...
Gespeichert in:
| Veröffentlicht in: | Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-12 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 12 |
|---|---|
| container_issue | 2020 |
| container_start_page | 1 |
| container_title | Oxidative medicine and cellular longevity |
| container_volume | 2020 |
| creator | Kim, Do-Yeon Coronado, Indiana Kim, Hyeon Ji Lee, Sang Min Kim, Tae-Jun Cho, Jin-Hwa Kang, Mingyu Yi, Dong-Keun |
| description | Neural stem/progenitor cells (NSPCs) are self-renewing, multipotent cells located in the embryonic and adult central nervous system (CNS). Extensive preclinical and clinical studies have shed light on the potential of stem cell replacement therapy for various neurodegenerative diseases. The key prerequisite for the success of these clinical applications is the procurement of a sufficient number of high-quality NSPCs. In this study, we explored the biological activity of Quadrella incana leaf in NSPC homeostasis. We showed that the leaf extract of Quadrella incana upregulated NSPC marker and proliferative potential. On the other hand, Quadrella incana leaf suppressed spontaneous unintended NSPC differentiation. Mechanistically, Quadrella incana leaf contributed to the maintenance of NSPCs by upregulating glycolytic flux and redox potential. |
| doi_str_mv | 10.1155/2020/5963037 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7201589</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A628177250</galeid><sourcerecordid>A628177250</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-afcf0bd05876eed06ec6e2a3f544ba2bbdaac06c8624e7f520189a636f124d9e3</originalsourceid><addsrcrecordid>eNqNkk2P0zAQQCMEYpeFG2dkiQsISidO4jQXpFXVXZAKLB97tqbOOPXKtbuOA-1v4k_i0lKWG6exNU9vZuzJsqc5vMnzqhpz4DCuGlFAUd_LTvOm5CNomvL-8Qxwkj3q-xsAUfAyf5id7EJeFHCa_fw8YBvIWmTGKXTIXkxxvcaAipBesjmhZrNNTPfIZm6JTlHProK3RlPAaLxj6Fr2AY2L5HZp5jX7SENAy75GWo0T3JEz0Qc2TYV6FpfBD92SXa8DdYNNEtexS7tV3m6jUezCDpvf0i_U-g278kkcDdrH2QONtqcnh3iWXV_Mvk3fjeafLt9Pz-cjVVYijlArDYsWqkktiFoQpARxLHRVlgvki0WLqECoieAl1brikE8aFIXQOS_bhoqz7O3eux4WK2pVqp6GketgVhi20qOR_2acWcrOf5d1UlWTJgmeHwTB3w7UR3njh-BSz5KXALyuq_wO1aElaZz2u1demV7Jc8EneV3zChL1ek-p4Ps-kD72kYPcLYDcLYA8LEDCn93t_Qj_-fEEvNoDS-Na_GH-U0eJIY1_aQ4VABS_AFCWxVw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2400277519</pqid></control><display><type>article</type><title>Quadrella incana (Capparaceae) Leaf Extract Enhances Proliferation and Maintenance of Neural Stem/Progenitor Cells through Upregulating Glycolytic Flux and Redox Potential</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Kim, Do-Yeon ; Coronado, Indiana ; Kim, Hyeon Ji ; Lee, Sang Min ; Kim, Tae-Jun ; Cho, Jin-Hwa ; Kang, Mingyu ; Yi, Dong-Keun</creator><contributor>Cipak Gasparovic, Ana ; Ana Cipak Gasparovic</contributor><creatorcontrib>Kim, Do-Yeon ; Coronado, Indiana ; Kim, Hyeon Ji ; Lee, Sang Min ; Kim, Tae-Jun ; Cho, Jin-Hwa ; Kang, Mingyu ; Yi, Dong-Keun ; Cipak Gasparovic, Ana ; Ana Cipak Gasparovic</creatorcontrib><description>Neural stem/progenitor cells (NSPCs) are self-renewing, multipotent cells located in the embryonic and adult central nervous system (CNS). Extensive preclinical and clinical studies have shed light on the potential of stem cell replacement therapy for various neurodegenerative diseases. The key prerequisite for the success of these clinical applications is the procurement of a sufficient number of high-quality NSPCs. In this study, we explored the biological activity of Quadrella incana leaf in NSPC homeostasis. We showed that the leaf extract of Quadrella incana upregulated NSPC marker and proliferative potential. On the other hand, Quadrella incana leaf suppressed spontaneous unintended NSPC differentiation. Mechanistically, Quadrella incana leaf contributed to the maintenance of NSPCs by upregulating glycolytic flux and redox potential.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2020/5963037</identifier><identifier>PMID: 32411330</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Animals ; Capparaceae - chemistry ; Cell Differentiation - drug effects ; Cell Proliferation - drug effects ; Ethylenediaminetetraacetic acid ; Genes ; Glycolysis - drug effects ; Homeostasis ; Immunoglobulins ; Laboratories ; Lactic Acid - metabolism ; Medical research ; Medicine, Experimental ; Membranes ; Metabolism ; Mice ; Nervous system diseases ; Neural Stem Cells - cytology ; Oxidation-Reduction - drug effects ; Oxidative stress ; Oxidative Stress - drug effects ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; Proto-Oncogene Proteins c-akt - metabolism ; Scientific equipment and supplies industry ; Stem cells ; TOR Serine-Threonine Kinases - metabolism ; Transplantation ; Up-Regulation - drug effects</subject><ispartof>Oxidative medicine and cellular longevity, 2020, Vol.2020 (2020), p.1-12</ispartof><rights>Copyright © 2020 Mingyu Kang et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Mingyu Kang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Mingyu Kang et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c456t-afcf0bd05876eed06ec6e2a3f544ba2bbdaac06c8624e7f520189a636f124d9e3</cites><orcidid>0000-0003-2200-7396</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201589/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201589/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27902,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32411330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cipak Gasparovic, Ana</contributor><contributor>Ana Cipak Gasparovic</contributor><creatorcontrib>Kim, Do-Yeon</creatorcontrib><creatorcontrib>Coronado, Indiana</creatorcontrib><creatorcontrib>Kim, Hyeon Ji</creatorcontrib><creatorcontrib>Lee, Sang Min</creatorcontrib><creatorcontrib>Kim, Tae-Jun</creatorcontrib><creatorcontrib>Cho, Jin-Hwa</creatorcontrib><creatorcontrib>Kang, Mingyu</creatorcontrib><creatorcontrib>Yi, Dong-Keun</creatorcontrib><title>Quadrella incana (Capparaceae) Leaf Extract Enhances Proliferation and Maintenance of Neural Stem/Progenitor Cells through Upregulating Glycolytic Flux and Redox Potential</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Neural stem/progenitor cells (NSPCs) are self-renewing, multipotent cells located in the embryonic and adult central nervous system (CNS). Extensive preclinical and clinical studies have shed light on the potential of stem cell replacement therapy for various neurodegenerative diseases. The key prerequisite for the success of these clinical applications is the procurement of a sufficient number of high-quality NSPCs. In this study, we explored the biological activity of Quadrella incana leaf in NSPC homeostasis. We showed that the leaf extract of Quadrella incana upregulated NSPC marker and proliferative potential. On the other hand, Quadrella incana leaf suppressed spontaneous unintended NSPC differentiation. Mechanistically, Quadrella incana leaf contributed to the maintenance of NSPCs by upregulating glycolytic flux and redox potential.</description><subject>Animals</subject><subject>Capparaceae - chemistry</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Genes</subject><subject>Glycolysis - drug effects</subject><subject>Homeostasis</subject><subject>Immunoglobulins</subject><subject>Laboratories</subject><subject>Lactic Acid - metabolism</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Membranes</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Nervous system diseases</subject><subject>Neural Stem Cells - cytology</subject><subject>Oxidation-Reduction - drug effects</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>Scientific equipment and supplies industry</subject><subject>Stem cells</subject><subject>TOR Serine-Threonine Kinases - metabolism</subject><subject>Transplantation</subject><subject>Up-Regulation - drug effects</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk2P0zAQQCMEYpeFG2dkiQsISidO4jQXpFXVXZAKLB97tqbOOPXKtbuOA-1v4k_i0lKWG6exNU9vZuzJsqc5vMnzqhpz4DCuGlFAUd_LTvOm5CNomvL-8Qxwkj3q-xsAUfAyf5id7EJeFHCa_fw8YBvIWmTGKXTIXkxxvcaAipBesjmhZrNNTPfIZm6JTlHProK3RlPAaLxj6Fr2AY2L5HZp5jX7SENAy75GWo0T3JEz0Qc2TYV6FpfBD92SXa8DdYNNEtexS7tV3m6jUezCDpvf0i_U-g278kkcDdrH2QONtqcnh3iWXV_Mvk3fjeafLt9Pz-cjVVYijlArDYsWqkktiFoQpARxLHRVlgvki0WLqECoieAl1brikE8aFIXQOS_bhoqz7O3eux4WK2pVqp6GketgVhi20qOR_2acWcrOf5d1UlWTJgmeHwTB3w7UR3njh-BSz5KXALyuq_wO1aElaZz2u1demV7Jc8EneV3zChL1ek-p4Ps-kD72kYPcLYDcLYA8LEDCn93t_Qj_-fEEvNoDS-Na_GH-U0eJIY1_aQ4VABS_AFCWxVw</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Kim, Do-Yeon</creator><creator>Coronado, Indiana</creator><creator>Kim, Hyeon Ji</creator><creator>Lee, Sang Min</creator><creator>Kim, Tae-Jun</creator><creator>Cho, Jin-Hwa</creator><creator>Kang, Mingyu</creator><creator>Yi, Dong-Keun</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2200-7396</orcidid></search><sort><creationdate>2020</creationdate><title>Quadrella incana (Capparaceae) Leaf Extract Enhances Proliferation and Maintenance of Neural Stem/Progenitor Cells through Upregulating Glycolytic Flux and Redox Potential</title><author>Kim, Do-Yeon ; Coronado, Indiana ; Kim, Hyeon Ji ; Lee, Sang Min ; Kim, Tae-Jun ; Cho, Jin-Hwa ; Kang, Mingyu ; Yi, Dong-Keun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-afcf0bd05876eed06ec6e2a3f544ba2bbdaac06c8624e7f520189a636f124d9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Capparaceae - chemistry</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Genes</topic><topic>Glycolysis - drug effects</topic><topic>Homeostasis</topic><topic>Immunoglobulins</topic><topic>Laboratories</topic><topic>Lactic Acid - metabolism</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Membranes</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Nervous system diseases</topic><topic>Neural Stem Cells - cytology</topic><topic>Oxidation-Reduction - drug effects</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves - chemistry</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>Scientific equipment and supplies industry</topic><topic>Stem cells</topic><topic>TOR Serine-Threonine Kinases - metabolism</topic><topic>Transplantation</topic><topic>Up-Regulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Do-Yeon</creatorcontrib><creatorcontrib>Coronado, Indiana</creatorcontrib><creatorcontrib>Kim, Hyeon Ji</creatorcontrib><creatorcontrib>Lee, Sang Min</creatorcontrib><creatorcontrib>Kim, Tae-Jun</creatorcontrib><creatorcontrib>Cho, Jin-Hwa</creatorcontrib><creatorcontrib>Kang, Mingyu</creatorcontrib><creatorcontrib>Yi, Dong-Keun</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Do-Yeon</au><au>Coronado, Indiana</au><au>Kim, Hyeon Ji</au><au>Lee, Sang Min</au><au>Kim, Tae-Jun</au><au>Cho, Jin-Hwa</au><au>Kang, Mingyu</au><au>Yi, Dong-Keun</au><au>Cipak Gasparovic, Ana</au><au>Ana Cipak Gasparovic</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quadrella incana (Capparaceae) Leaf Extract Enhances Proliferation and Maintenance of Neural Stem/Progenitor Cells through Upregulating Glycolytic Flux and Redox Potential</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Neural stem/progenitor cells (NSPCs) are self-renewing, multipotent cells located in the embryonic and adult central nervous system (CNS). Extensive preclinical and clinical studies have shed light on the potential of stem cell replacement therapy for various neurodegenerative diseases. The key prerequisite for the success of these clinical applications is the procurement of a sufficient number of high-quality NSPCs. In this study, we explored the biological activity of Quadrella incana leaf in NSPC homeostasis. We showed that the leaf extract of Quadrella incana upregulated NSPC marker and proliferative potential. On the other hand, Quadrella incana leaf suppressed spontaneous unintended NSPC differentiation. Mechanistically, Quadrella incana leaf contributed to the maintenance of NSPCs by upregulating glycolytic flux and redox potential.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32411330</pmid><doi>10.1155/2020/5963037</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-2200-7396</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1942-0900 |
| ispartof | Oxidative medicine and cellular longevity, 2020, Vol.2020 (2020), p.1-12 |
| issn | 1942-0900 1942-0994 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7201589 |
| source | MEDLINE; Wiley Online Library Open Access; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Animals Capparaceae - chemistry Cell Differentiation - drug effects Cell Proliferation - drug effects Ethylenediaminetetraacetic acid Genes Glycolysis - drug effects Homeostasis Immunoglobulins Laboratories Lactic Acid - metabolism Medical research Medicine, Experimental Membranes Metabolism Mice Nervous system diseases Neural Stem Cells - cytology Oxidation-Reduction - drug effects Oxidative stress Oxidative Stress - drug effects Plant Extracts - pharmacology Plant Leaves - chemistry Proto-Oncogene Proteins c-akt - metabolism Scientific equipment and supplies industry Stem cells TOR Serine-Threonine Kinases - metabolism Transplantation Up-Regulation - drug effects |
| title | Quadrella incana (Capparaceae) Leaf Extract Enhances Proliferation and Maintenance of Neural Stem/Progenitor Cells through Upregulating Glycolytic Flux and Redox Potential |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T18%3A52%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Quadrella%20incana%20(Capparaceae)%20Leaf%20Extract%20Enhances%20Proliferation%20and%20Maintenance%20of%20Neural%20Stem/Progenitor%20Cells%20through%20Upregulating%20Glycolytic%20Flux%20and%20Redox%20Potential&rft.jtitle=Oxidative%20medicine%20and%20cellular%20longevity&rft.au=Kim,%20Do-Yeon&rft.date=2020&rft.volume=2020&rft.issue=2020&rft.spage=1&rft.epage=12&rft.pages=1-12&rft.issn=1942-0900&rft.eissn=1942-0994&rft_id=info:doi/10.1155/2020/5963037&rft_dat=%3Cgale_pubme%3EA628177250%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2400277519&rft_id=info:pmid/32411330&rft_galeid=A628177250&rfr_iscdi=true |