The polygenic architecture of left ventricular mass mirrors the clinical epidemiology

Left ventricular (LV) mass is a prognostic biomarker for incident heart disease and all-cause mortality. Large-scale genome-wide association studies have identified few SNPs associated with LV mass. We hypothesized that a polygenic discovery approach using LV mass measurements made in a clinical pop...

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Veröffentlicht in:	Scientific reports 2020-05, Vol.10 (1), p.7561-7561, Article 7561
Hauptverfasser:	Mosley, Jonathan D., Levinson, Rebecca T., Farber-Eger, Eric, Edwards, Todd L., Hellwege, Jacklyn N., Hung, Adriana M., Giri, Ayush, Shuey, Megan M., Shaffer, Christian M., Shi, Mingjian, Brittain, Evan L., Chung, Wendy K., Kullo, Iftikhar J., Arruda-Olson, Adelaide M., Jarvik, Gail P., Larson, Eric B., Crosslin, David R., Williams, Marc S., Borthwick, Ken M., Hakonarson, Hakon, Denny, Joshua C., Wang, Thomas J., Stein, Charles M., Roden, Dan M., Wells, Quinn S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/205 692/4019/592/1540 Arteriosclerosis Blood pressure Body mass index Cardiovascular diseases Congestive heart failure Coronary artery disease Echocardiography Epidemiology Female Fibrillation Genetic analysis Genetic Predisposition to Disease Genetic variability Genome-wide association studies Genome-Wide Association Study Genomes Genotype Health risk assessment Heart Diseases - diagnosis Heart Diseases - epidemiology Heart Diseases - etiology Heart Diseases - mortality Heart Ventricles - anatomy & histology Heart Ventricles - diagnostic imaging Heart Ventricles - pathology Humanities and Social Sciences Humans Male multidisciplinary Multifactorial Inheritance Odds Ratio Organ Size Phenotype Phenotypes Polymorphism, Single Nucleotide Risk Assessment Risk Factors Science Science (multidisciplinary) Single-nucleotide polymorphism Ventricle Ventricular Remodeling - genetics
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