Immunology of COVID-19: Current State of the Science

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2020-06, Vol.52 (6), p.910-941
Hauptverfasser:	Vabret, Nicolas, Britton, Graham J., Gruber, Conor, Hegde, Samarth, Kim, Joel, Kuksin, Maria, Levantovsky, Rachel, Malle, Louise, Moreira, Alvaro, Park, Matthew D., Pia, Luisanna, Risson, Emma, Saffern, Miriam, Salomé, Bérengère, Esai Selvan, Myvizhi, Spindler, Matthew P., Tan, Jessica, van der Heide, Verena, Gregory, Jill K., Alexandropoulos, Konstantina, Bhardwaj, Nina, Brown, Brian D., Greenbaum, Benjamin, Gümüş, Zeynep H., Homann, Dirk, Horowitz, Amir, Kamphorst, Alice O., Curotto de Lafaille, Maria A., Mehandru, Saurabh, Merad, Miriam, Samstein, Robert M., Agrawal, Manasi, Aleynick, Mark, Belabed, Meriem, Brown, Matthew, Casanova-Acebes, Maria, Catalan, Jovani, Centa, Monica, Charap, Andrew, Chan, Andrew, Chen, Steven T., Chung, Jonathan, Bozkus, Cansu Cimen, Cody, Evan, Cossarini, Francesca, Dalla, Erica, Fernandez, Nicolas, Grout, John, Ruan, Dan Fu, Hamon, Pauline, Humblin, Etienne, Jha, Divya, Kodysh, Julia, Leader, Andrew, Lin, Matthew, Lindblad, Katherine, Lozano-Ojalvo, Daniel, Lubitz, Gabrielle, Magen, Assaf, Mahmood, Zafar, Martinez-Delgado, Gustavo, Mateus-Tique, Jaime, Meritt, Elliot, Moon, Chang, Noel, Justine, O’Donnell, Tim, Ota, Miyo, Plitt, Tamar, Pothula, Venu, Redes, Jamie, Reyes Torres, Ivan, Roberto, Mark, Sanchez-Paulete, Alfonso R., Shang, Joan, Schanoski, Alessandra Soares, Suprun, Maria, Tran, Michelle, Vaninov, Natalie, Wilk, C. Matthias, Aguirre-Ghiso, Julio, Bogunovic, Dusan, Cho, Judy, Faith, Jeremiah, Grasset, Emilie, Heeger, Peter, Kenigsberg, Ephraim, Krammer, Florian, Laserson, Uri
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Animals Betacoronavirus - physiology Clinical trials Coronaviridae Coronavirus Infections - diagnosis Coronavirus Infections - immunology Coronavirus Infections - pathology Coronavirus Infections - therapy Coronaviruses COVID-19 Cytokines Disease Susceptibility Disease transmission Epidemics Humans Immune response Immunity, Innate Immunologic Memory Immunology Infections Inflammation - immunology Inflammation - virology Life Sciences & Biomedicine Lymphocytes - immunology Middle East respiratory syndrome Myeloid Cells - immunology Pandemics Pathophysiology Phosphorylation Pneumonia, Viral - diagnosis Pneumonia, Viral - immunology Pneumonia, Viral - pathology Pneumonia, Viral - therapy Proteins Respiratory diseases Review SARS-CoV-2 Science & Technology Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Signal transduction Tumor necrosis factor-TNF Viral diseases Viral infections Viruses Zoonoses
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Zusammenfassung:	The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection. The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.
ISSN:	1074-7613 1097-4180 1097-4180
DOI:	10.1016/j.immuni.2020.05.002