Nek2-mediated GAS2L1 phosphorylation and centrosome-linker disassembly induce centrosome disjunction

Centrosome disjunction occurs in late G2 to facilitate bipolar spindle formation and is mediated by the NIMA-related kinase Nek2. Here, we show that GAS2L1, a microtubule- and F-actin-binding protein required for centrosome disjunction, undergoes Nek2-mediated phosphorylation at Ser352 in G2/M. The...

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Veröffentlicht in:	The Journal of cell biology 2020-05, Vol.219 (5)
Hauptverfasser:	Au, Franco K C, Hau, Bill K T, Qi, Robert Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Calcium-Binding Proteins - genetics Calponins Cancer Cell Cycle and Division Centrosome - metabolism Chromosome Segregation - genetics HEK293 Cells HeLa Cells Humans Microfilament Proteins - genetics Microtubules - genetics Mitosis - genetics NIMA-Related Kinases - genetics Phosphorylation Protein Domains - genetics Spindle Apparatus - genetics
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