Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge

Abstract Nipah virus (NiV) is a highly pathogenic zoonotic paramyxovirus that causes fatal encephalitis and respiratory disease in humans. There is currently no approved therapeutic for human use against NiV infection. Griffithsin (GRFT) is high-mannose oligosaccharide binding lectin that has shown...

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Veröffentlicht in:	The Journal of infectious diseases 2020-05, Vol.221 (Supplement_4), p.S480-S492
Hauptverfasser:	Lo, Michael K, Spengler, Jessica R, Krumpe, Lauren R H, Welch, Stephen R, Chattopadhyay, Anasuya, Harmon, Jessica R, Coleman-McCray, JoAnn D, Scholte, Florine E M, Hotard, Anne L, Fuqua, Joshua L, Rose, John K, Nichol, Stuart T, Palmer, Kenneth E, O’Keefe, Barry R, Spiropoulou, Christina F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Antiviral drugs Chlorocebus aethiops Coronaviruses Disease Models, Animal Drug Evaluation, Preclinical Encephalitis Female HEK293 Cells HeLa Cells Henipavirus Infections - drug therapy Henipavirus Infections - virology Hepatitis C HIV Human immunodeficiency virus Humans Mannose Mesocricetus Nipah Virus - drug effects Nipah Virus - isolation & purification Oligosaccharides Oxidation Plant Lectins - pharmacology Plant Lectins - therapeutic use Respiratory diseases Severe acute respiratory syndrome Supplement Syncytia Vero Cells Virus Internalization - drug effects Viruses Zoonoses
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