Homeostatic maintenance and age-related functional decline in the Drosophila ear
Age-related hearing loss (ARHL) is a threat to future human wellbeing. Multiple factors contributing to the terminal auditory decline have been identified; but a unified understanding of ARHL - or the homeostatic maintenance of hearing before its breakdown - is missing. We here present an in-depth a...
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| creator | Keder, Alyona Tardieu, Camille Malong, Liza Filia, Anastasia Kashkenbayeva, Assel Newton, Fay Georgiades, Marcos Gale, Jonathan E. Lovett, Michael Jarman, Andrew P. Albert, Joerg T. |
| description | Age-related hearing loss (ARHL) is a threat to future human wellbeing. Multiple factors contributing to the terminal auditory decline have been identified; but a unified understanding of ARHL - or the homeostatic maintenance of hearing before its breakdown - is missing. We here present an in-depth analysis of homeostasis and ageing in the antennal ears of the fruit fly
Drosophila melanogaster
. We show that
Drosophila
, just like humans, display ARHL. By focusing on the phase of dynamic stability prior to the eventual hearing loss we discovered a set of evolutionarily conserved homeostasis genes. The transcription factors Onecut (closest human orthologues: ONECUT2, ONECUT3), Optix (SIX3, SIX6), Worniu (SNAI2) and Amos (ATOH1, ATOH7, ATOH8, NEUROD1) emerged as key regulators, acting upstream of core components of the fly’s molecular machinery for auditory transduction and amplification. Adult-specific manipulation of homeostatic regulators in the fly’s auditory neurons accelerated - or protected against - ARHL. |
| doi_str_mv | 10.1038/s41598-020-64498-z |
| format | Article |
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Drosophila melanogaster
. We show that
Drosophila
, just like humans, display ARHL. By focusing on the phase of dynamic stability prior to the eventual hearing loss we discovered a set of evolutionarily conserved homeostasis genes. The transcription factors Onecut (closest human orthologues: ONECUT2, ONECUT3), Optix (SIX3, SIX6), Worniu (SNAI2) and Amos (ATOH1, ATOH7, ATOH8, NEUROD1) emerged as key regulators, acting upstream of core components of the fly’s molecular machinery for auditory transduction and amplification. Adult-specific manipulation of homeostatic regulators in the fly’s auditory neurons accelerated - or protected against - ARHL.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-64498-z</identifier><identifier>PMID: 32366993</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378 ; 631/378/2619 ; Aging ; Animals ; Arthropod Antennae - physiology ; Beta2 protein ; Drosophila ; Drosophila melanogaster - physiology ; Drosophila Proteins - genetics ; Ear ; Ears & hearing ; Female ; Genotype ; Hearing - genetics ; Hearing loss ; Hearing Loss - genetics ; Homeodomain Proteins - genetics ; Homeostasis ; Humanities and Social Sciences ; Humans ; Insects ; Male ; Math1 protein ; Mice ; multidisciplinary ; Nerve Growth Factors - genetics ; Nerve Tissue Proteins - genetics ; Neurons - physiology ; RNA Interference ; Science ; Science (multidisciplinary) ; Sequence Analysis, RNA ; SIX gene family ; Snail protein ; Sound ; Time Factors ; Trans-Activators - genetics ; Transcription factors ; Transcription Factors - genetics ; Transcriptome</subject><ispartof>Scientific reports, 2020-05, Vol.10 (1), p.7431-7431, Article 7431</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-7f865ae721538a875796b08b821eee1d073ef2693125b7a66cb5ecbc68d1bbaa3</citedby><cites>FETCH-LOGICAL-c540t-7f865ae721538a875796b08b821eee1d073ef2693125b7a66cb5ecbc68d1bbaa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198581/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198581/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32366993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keder, Alyona</creatorcontrib><creatorcontrib>Tardieu, Camille</creatorcontrib><creatorcontrib>Malong, Liza</creatorcontrib><creatorcontrib>Filia, Anastasia</creatorcontrib><creatorcontrib>Kashkenbayeva, Assel</creatorcontrib><creatorcontrib>Newton, Fay</creatorcontrib><creatorcontrib>Georgiades, Marcos</creatorcontrib><creatorcontrib>Gale, Jonathan E.</creatorcontrib><creatorcontrib>Lovett, Michael</creatorcontrib><creatorcontrib>Jarman, Andrew P.</creatorcontrib><creatorcontrib>Albert, Joerg T.</creatorcontrib><title>Homeostatic maintenance and age-related functional decline in the Drosophila ear</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Age-related hearing loss (ARHL) is a threat to future human wellbeing. Multiple factors contributing to the terminal auditory decline have been identified; but a unified understanding of ARHL - or the homeostatic maintenance of hearing before its breakdown - is missing. We here present an in-depth analysis of homeostasis and ageing in the antennal ears of the fruit fly
Drosophila melanogaster
. We show that
Drosophila
, just like humans, display ARHL. By focusing on the phase of dynamic stability prior to the eventual hearing loss we discovered a set of evolutionarily conserved homeostasis genes. The transcription factors Onecut (closest human orthologues: ONECUT2, ONECUT3), Optix (SIX3, SIX6), Worniu (SNAI2) and Amos (ATOH1, ATOH7, ATOH8, NEUROD1) emerged as key regulators, acting upstream of core components of the fly’s molecular machinery for auditory transduction and amplification. Adult-specific manipulation of homeostatic regulators in the fly’s auditory neurons accelerated - or protected against - ARHL.</description><subject>631/378</subject><subject>631/378/2619</subject><subject>Aging</subject><subject>Animals</subject><subject>Arthropod Antennae - physiology</subject><subject>Beta2 protein</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - physiology</subject><subject>Drosophila Proteins - genetics</subject><subject>Ear</subject><subject>Ears & hearing</subject><subject>Female</subject><subject>Genotype</subject><subject>Hearing - genetics</subject><subject>Hearing loss</subject><subject>Hearing Loss - genetics</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeostasis</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Insects</subject><subject>Male</subject><subject>Math1 protein</subject><subject>Mice</subject><subject>multidisciplinary</subject><subject>Nerve Growth Factors - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keder, Alyona</au><au>Tardieu, Camille</au><au>Malong, Liza</au><au>Filia, Anastasia</au><au>Kashkenbayeva, Assel</au><au>Newton, Fay</au><au>Georgiades, Marcos</au><au>Gale, Jonathan E.</au><au>Lovett, Michael</au><au>Jarman, Andrew P.</au><au>Albert, Joerg T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Homeostatic maintenance and age-related functional decline in the Drosophila ear</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-05-04</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>7431</spage><epage>7431</epage><pages>7431-7431</pages><artnum>7431</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Age-related hearing loss (ARHL) is a threat to future human wellbeing. Multiple factors contributing to the terminal auditory decline have been identified; but a unified understanding of ARHL - or the homeostatic maintenance of hearing before its breakdown - is missing. We here present an in-depth analysis of homeostasis and ageing in the antennal ears of the fruit fly
Drosophila melanogaster
. We show that
Drosophila
, just like humans, display ARHL. By focusing on the phase of dynamic stability prior to the eventual hearing loss we discovered a set of evolutionarily conserved homeostasis genes. The transcription factors Onecut (closest human orthologues: ONECUT2, ONECUT3), Optix (SIX3, SIX6), Worniu (SNAI2) and Amos (ATOH1, ATOH7, ATOH8, NEUROD1) emerged as key regulators, acting upstream of core components of the fly’s molecular machinery for auditory transduction and amplification. Adult-specific manipulation of homeostatic regulators in the fly’s auditory neurons accelerated - or protected against - ARHL.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32366993</pmid><doi>10.1038/s41598-020-64498-z</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/378 631/378/2619 Aging Animals Arthropod Antennae - physiology Beta2 protein Drosophila Drosophila melanogaster - physiology Drosophila Proteins - genetics Ear Ears & hearing Female Genotype Hearing - genetics Hearing loss Hearing Loss - genetics Homeodomain Proteins - genetics Homeostasis Humanities and Social Sciences Humans Insects Male Math1 protein Mice multidisciplinary Nerve Growth Factors - genetics Nerve Tissue Proteins - genetics Neurons - physiology RNA Interference Science Science (multidisciplinary) Sequence Analysis, RNA SIX gene family Snail protein Sound Time Factors Trans-Activators - genetics Transcription factors Transcription Factors - genetics Transcriptome |
| title | Homeostatic maintenance and age-related functional decline in the Drosophila ear |
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