Back-Table Fluorescence-Guided Imaging for Circumferential Resection Margin Evaluation Using Bevacizumab-800CW in Patients with Locally Advanced Rectal Cancer

Negative circumferential resection margins (CRM) are the cornerstone for the curative treatment of locally advanced rectal cancer (LARC). However, in up to 18.6% of patients, tumor-positive resection margins are detected on histopathology. In this proof-of-concept study, we investigated the feasibil...

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Veröffentlicht in:	Journal of Nuclear Medicine 2020-05, Vol.61 (5), p.655-661
Hauptverfasser:	de Jongh, Steven J, Tjalma, Jolien J J, Koller, Marjory, Linssen, Matthijs D, Vonk, Jasper, Dobosz, Michael, Jorritsma-Smit, Annelies, Kleibeuker, Jan H, Hospers, Geke A P, Havenga, Klaas, Hemmer, Patrick H J, Karrenbeld, Arend, van Dam, Gooitzen M, van Etten, Boudewijn, Nagengast, Wouter B
Format:	Artikel
Sprache:	eng
Schlagworte:	Bevacizumab Cancer Chemoradiotherapy Colorectal cancer Decision making Drug delivery systems Feasibility studies Fluorescence Fluorescence microscopy Formaldehyde Growth factors Histopathology Immunotherapy Intravenous administration Medical imaging Monoclonal antibodies Oncology Optimization Patients Radiation Radiation therapy Rectum Sensitivity Surgery Targeted cancer therapy Tissues Tumors Vascular endothelial growth factor
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