Dose–response time modelling for highly pathogenic avian influenza A (H5N1) virus infection
Aims: To develop time‐dependent dose–response models for highly pathogenic avian influenza A (HPAI) of the H5N1 subtype virus. Methods and Results: A total of four candidate time‐dependent dose–response models were fitted to four survival data sets for animals (mice or ferrets) exposed to graded dos...
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| Veröffentlicht in: | Letters in applied microbiology 2011-10, Vol.53 (4), p.438-444 |
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| creator | Kitajima, M Huang, Y Watanabe, T Katayama, H Haas, C.N |
| description | Aims: To develop time‐dependent dose–response models for highly pathogenic avian influenza A (HPAI) of the H5N1 subtype virus. Methods and Results: A total of four candidate time‐dependent dose–response models were fitted to four survival data sets for animals (mice or ferrets) exposed to graded doses of HPAI H5N1 virus using the maximum‐likelihood estimation. A beta‐Poisson dose–response model with the N50 parameter modified by an exponential‐inverse‐power time dependency or an exponential dose–response model with the k parameter modified by an exponential‐inverse time dependency provided a statistically adequate fit to the observed survival data. Conclusions: We have successfully developed the time‐dependent dose–response models to describe the mortality of animals exposed to an HPAI H5N1 virus. The developed model describes the mortality over time and represents observed experimental responses accurately. Significance and Impact of the Study: This is the first study describing time‐dependent dose–response models for HPAI H5N1 virus. The developed models will be a useful tool for estimating the mortality of HPAI H5N1 virus, which may depend on time postexposure, for the preparation of a future influenza pandemic caused by this lethal virus. |
| doi_str_mv | 10.1111/j.1472-765X.2011.03128.x |
| format | Article |
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Methods and Results: A total of four candidate time‐dependent dose–response models were fitted to four survival data sets for animals (mice or ferrets) exposed to graded doses of HPAI H5N1 virus using the maximum‐likelihood estimation. A beta‐Poisson dose–response model with the N50 parameter modified by an exponential‐inverse‐power time dependency or an exponential dose–response model with the k parameter modified by an exponential‐inverse time dependency provided a statistically adequate fit to the observed survival data. Conclusions: We have successfully developed the time‐dependent dose–response models to describe the mortality of animals exposed to an HPAI H5N1 virus. The developed model describes the mortality over time and represents observed experimental responses accurately. Significance and Impact of the Study: This is the first study describing time‐dependent dose–response models for HPAI H5N1 virus. The developed models will be a useful tool for estimating the mortality of HPAI H5N1 virus, which may depend on time postexposure, for the preparation of a future influenza pandemic caused by this lethal virus.</description><identifier>ISSN: 0266-8254</identifier><identifier>EISSN: 1472-765X</identifier><identifier>DOI: 10.1111/j.1472-765X.2011.03128.x</identifier><identifier>PMID: 21790679</identifier><identifier>CODEN: LAMIE7</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; avian influenza ; Biological and medical sciences ; data collection ; Disease Models, Animal ; disease(s) ; Ferrets ; Fundamental and applied biological sciences. Psychology ; infection ; Influenza A virus ; Influenza A Virus, H5N1 Subtype - pathogenicity ; Mice ; Microbiology ; modelling ; Models, Statistical ; mortality ; Mustela ; Original ; Orthomyxoviridae Infections - mortality ; Orthomyxoviridae Infections - virology ; pandemic ; Survival Analysis ; virulence ; virus(es) ; viruses</subject><ispartof>Letters in applied microbiology, 2011-10, Vol.53 (4), p.438-444</ispartof><rights>2011 The Authors. Letters in Applied Microbiology © 2011 The Society for Applied Microbiology</rights><rights>2015 INIST-CNRS</rights><rights>2011 The Authors. Letters in Applied Microbiology © 2011 The Society for Applied Microbiology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5108-edb5fd5f2ffaec4c38684eca68cb0a755f76007886659c60720d7cdb60a88ab73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1472-765X.2011.03128.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1472-765X.2011.03128.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24520418$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21790679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kitajima, M</creatorcontrib><creatorcontrib>Huang, Y</creatorcontrib><creatorcontrib>Watanabe, T</creatorcontrib><creatorcontrib>Katayama, H</creatorcontrib><creatorcontrib>Haas, C.N</creatorcontrib><title>Dose–response time modelling for highly pathogenic avian influenza A (H5N1) virus infection</title><title>Letters in applied microbiology</title><addtitle>Lett Appl Microbiol</addtitle><description>Aims: To develop time‐dependent dose–response models for highly pathogenic avian influenza A (HPAI) of the H5N1 subtype virus. Methods and Results: A total of four candidate time‐dependent dose–response models were fitted to four survival data sets for animals (mice or ferrets) exposed to graded doses of HPAI H5N1 virus using the maximum‐likelihood estimation. A beta‐Poisson dose–response model with the N50 parameter modified by an exponential‐inverse‐power time dependency or an exponential dose–response model with the k parameter modified by an exponential‐inverse time dependency provided a statistically adequate fit to the observed survival data. Conclusions: We have successfully developed the time‐dependent dose–response models to describe the mortality of animals exposed to an HPAI H5N1 virus. The developed model describes the mortality over time and represents observed experimental responses accurately. Significance and Impact of the Study: This is the first study describing time‐dependent dose–response models for HPAI H5N1 virus. The developed models will be a useful tool for estimating the mortality of HPAI H5N1 virus, which may depend on time postexposure, for the preparation of a future influenza pandemic caused by this lethal virus.</description><subject>Animals</subject><subject>avian influenza</subject><subject>Biological and medical sciences</subject><subject>data collection</subject><subject>Disease Models, Animal</subject><subject>disease(s)</subject><subject>Ferrets</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>infection</subject><subject>Influenza A virus</subject><subject>Influenza A Virus, H5N1 Subtype - pathogenicity</subject><subject>Mice</subject><subject>Microbiology</subject><subject>modelling</subject><subject>Models, Statistical</subject><subject>mortality</subject><subject>Mustela</subject><subject>Original</subject><subject>Orthomyxoviridae Infections - mortality</subject><subject>Orthomyxoviridae Infections - virology</subject><subject>pandemic</subject><subject>Survival Analysis</subject><subject>virulence</subject><subject>virus(es)</subject><subject>viruses</subject><issn>0266-8254</issn><issn>1472-765X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks2O0zAUhS0EYjoDrwDeIGCRYDvxTxaDVA0_g1RgASOxQZbj2Kmr1C5x0pmy4h14Q54Eh5YCK7yxpfPd66tzDwAQoxyn82yV45KTjDP6KScI4xwVmIj85haYHYXbYIYIY5kgtDwBpzGuEEICk-ouOCGYV4jxagY-vwjR_Pj2vTdxE3w0cHBrA9ehMV3nfAtt6OHStctuBzdqWIbWeKeh2jrlofO2G43_quAcPrmk7_BTuHX9GCfB6MEFfw_csaqL5v7hPgNXr15-vLjMFu9fv7mYLzJNMRKZaWpqG2qJtcroUheCidJoxYSukeKUWs4Q4kIwRivNECeo4bqpGVJCqJoXZ-D5vu9mrNem0cYPverkpndr1e9kUE7-q3i3lG3YSo4rLqqpweNDgz58GU0c5NpFnTxQ3oQxyiq5zhBF-L-kEBXmjLEikQ_-Huo4zW_zE_DoAKioVWd75bWLf7iSElRikbjzPXftOrM76hjJKQxyJaedy2nncgqD_BUGeSMX87fTK9U_3NdbFaRq-_TH1YdElikQtEBMFD8BEFyy-w</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Kitajima, M</creator><creator>Huang, Y</creator><creator>Watanabe, T</creator><creator>Katayama, H</creator><creator>Haas, C.N</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>201110</creationdate><title>Dose–response time modelling for highly pathogenic avian influenza A (H5N1) virus infection</title><author>Kitajima, M ; Huang, Y ; Watanabe, T ; Katayama, H ; Haas, C.N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5108-edb5fd5f2ffaec4c38684eca68cb0a755f76007886659c60720d7cdb60a88ab73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>avian influenza</topic><topic>Biological and medical sciences</topic><topic>data collection</topic><topic>Disease Models, Animal</topic><topic>disease(s)</topic><topic>Ferrets</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>infection</topic><topic>Influenza A virus</topic><topic>Influenza A Virus, H5N1 Subtype - pathogenicity</topic><topic>Mice</topic><topic>Microbiology</topic><topic>modelling</topic><topic>Models, Statistical</topic><topic>mortality</topic><topic>Mustela</topic><topic>Original</topic><topic>Orthomyxoviridae Infections - mortality</topic><topic>Orthomyxoviridae Infections - virology</topic><topic>pandemic</topic><topic>Survival Analysis</topic><topic>virulence</topic><topic>virus(es)</topic><topic>viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kitajima, M</creatorcontrib><creatorcontrib>Huang, Y</creatorcontrib><creatorcontrib>Watanabe, T</creatorcontrib><creatorcontrib>Katayama, H</creatorcontrib><creatorcontrib>Haas, C.N</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Letters in applied microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kitajima, M</au><au>Huang, Y</au><au>Watanabe, T</au><au>Katayama, H</au><au>Haas, C.N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose–response time modelling for highly pathogenic avian influenza A (H5N1) virus infection</atitle><jtitle>Letters in applied microbiology</jtitle><addtitle>Lett Appl Microbiol</addtitle><date>2011-10</date><risdate>2011</risdate><volume>53</volume><issue>4</issue><spage>438</spage><epage>444</epage><pages>438-444</pages><issn>0266-8254</issn><eissn>1472-765X</eissn><coden>LAMIE7</coden><abstract>Aims: To develop time‐dependent dose–response models for highly pathogenic avian influenza A (HPAI) of the H5N1 subtype virus. Methods and Results: A total of four candidate time‐dependent dose–response models were fitted to four survival data sets for animals (mice or ferrets) exposed to graded doses of HPAI H5N1 virus using the maximum‐likelihood estimation. A beta‐Poisson dose–response model with the N50 parameter modified by an exponential‐inverse‐power time dependency or an exponential dose–response model with the k parameter modified by an exponential‐inverse time dependency provided a statistically adequate fit to the observed survival data. Conclusions: We have successfully developed the time‐dependent dose–response models to describe the mortality of animals exposed to an HPAI H5N1 virus. The developed model describes the mortality over time and represents observed experimental responses accurately. Significance and Impact of the Study: This is the first study describing time‐dependent dose–response models for HPAI H5N1 virus. The developed models will be a useful tool for estimating the mortality of HPAI H5N1 virus, which may depend on time postexposure, for the preparation of a future influenza pandemic caused by this lethal virus.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21790679</pmid><doi>10.1111/j.1472-765X.2011.03128.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals avian influenza Biological and medical sciences data collection Disease Models, Animal disease(s) Ferrets Fundamental and applied biological sciences. Psychology infection Influenza A virus Influenza A Virus, H5N1 Subtype - pathogenicity Mice Microbiology modelling Models, Statistical mortality Mustela Original Orthomyxoviridae Infections - mortality Orthomyxoviridae Infections - virology pandemic Survival Analysis virulence virus(es) viruses |
| title | Dose–response time modelling for highly pathogenic avian influenza A (H5N1) virus infection |
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