Atomic force microscopy–based characterization of the interaction of PriA helicase with stalled DNA replication forks

In bacteria, the restart of stalled DNA replication forks requires the DNA helicase PriA. PriA can recognize and remodel abandoned DNA replication forks, unwind DNA in the 3′-to-5′ direction, and facilitate the loading of the helicase DnaB onto the DNA to restart replication. Single-stranded DNA–bin...

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Veröffentlicht in:	The Journal of biological chemistry 2020-05, Vol.295 (18), p.6043-6052
Hauptverfasser:	Wang, Yaqing, Sun, Zhiqiang, Bianco, Piero R., Lyubchenko, Yuri L.
Format:	Artikel
Sprache:	eng
Schlagworte:	atomic force microscopy (AFM) DNA - genetics DNA - metabolism DNA helicase DNA Helicases - metabolism DNA Replication Microscopy, Atomic Force Molecular Biophysics protein translocation protein–DNA interaction single-molecule biophysics Substrate Specificity
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