Biophysical characterization of SARAH domain–mediated multimerization of Hippo pathway complexes in Drosophila

Hippo pathway signaling limits cell growth and proliferation and maintains the stem-cell niche. These cellular events result from the coordinated activity of a core kinase cassette that is regulated, in part, by interactions involving Hippo, Salvador, and dRassF. These interactions are mediated by a...

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Veröffentlicht in:	The Journal of biological chemistry 2020-05, Vol.295 (18), p.6202-6213
Hauptverfasser:	Cairns, Leah, Patterson, Angela, Weingartner, Kyler A., Koehler, T.J., DeAngelis, Daniel R., Tripp, Katherine W., Bothner, Brian, Kavran, Jennifer M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cell proliferation cell signaling Drosophila melanogaster Drosophila Proteins - chemistry Drosophila Proteins - metabolism Hippo pathway Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - metabolism Models, Molecular Molecular Biophysics MST2 (mammalian sterile 20-like kinase 2) Protein Domains Protein Multimerization protein-protein interaction Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - metabolism Salvador (sav) SARAH domain Sav/RassF/Hpo domain structure-function
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