AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice

Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic properties. However, the endogenous regulation of FAHFAs remains a pressing but unanswered question. Here, using MS-based FAHFA hydrolysis assays, LC-MS–based l...

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Veröffentlicht in:	The Journal of biological chemistry 2020-05, Vol.295 (18), p.5891-5905
Hauptverfasser:	Erikci Ertunc, Meric, Kok, Bernard P., Parsons, William H., Wang, Justin G., Tan, Dan, Donaldson, Cynthia J., Pinto, Antonio F.M., Vaughan, Joan M., Ngo, Nhi, Lum, Kenneth M., Henry, Cassandra L., Coppola, Aundrea R., Niphakis, Micah J., Cravatt, Benjamin F., Saez, Enrique, Saghatelian, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	androgen induced gene 1 (AIG1) androgen-dependent TFPI-regulating protein (ADTRP) Animals diabetes enzyme inhibitor Esterases - deficiency Esterases - genetics Esterases - metabolism Esters - chemistry fatty acid ester of hydroxy fatty acid (FAHFA) Fatty Acids - chemistry Fatty Acids - metabolism Gene Knockout Techniques glucose metabolism Hydrolysis lipid ester lipid signaling Lipids Membrane Proteins - deficiency Membrane Proteins - genetics Membrane Proteins - metabolism metabolism Mice threonine hydrolase
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