Phosphotyrosine-based Phosphoproteomics for Target Identification and Drug Response Prediction in AML Cell Lines

Phosphotyrosine (pY)-specific phosphoproteome profiles have been determined for 16 AML cell lines through a pY immunoprecipitation-based protocol. Kinase activity inference using dedicated ranking analysis, combining kinome-, activation loop-, and substrate-based analyses, identified potential drive...

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Veröffentlicht in:	Molecular & cellular proteomics 2020-05, Vol.19 (5), p.884-899
Hauptverfasser:	van Alphen, Carolien, Cloos, Jacqueline, Beekhof, Robin, Cucchi, David G.J., Piersma, Sander R., Knol, Jaco C., Henneman, Alex A., Pham, Thang V., van Meerloo, Johan, Ossenkoppele, Gert J., Verheul, Henk M.W., Janssen, Jeroen J.W.M., Jimenez, Connie R.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute myeloid leukemia Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cell Line, Tumor cell signaling Cluster Analysis Computer Simulation drug targets fms-Like Tyrosine Kinase 3 - metabolism Humans kinase inhibitors Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology MAP Kinase Signaling System mass spectrometry molecular biology Molecular Targeted Therapy Mutation - genetics personalized medicine phosphoproteome phosphoproteomics Phosphorylation - drug effects Phosphotyrosine - metabolism Protein Kinases - metabolism Proteome - metabolism Proteomics receptor tyrosine kinases Reproducibility of Results Tyrosine kinases
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