Low-Attenuation Noncalcified Plaque on Coronary Computed Tomography Angiography Predicts Myocardial Infarction: Results From the Multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART)

The future risk of myocardial infarction is commonly assessed using cardiovascular risk scores, coronary artery calcium score, or coronary artery stenosis severity. We assessed whether noncalcified low-attenuation plaque burden on coronary CT angiography (CCTA) might be a better predictor of the fut...

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Veröffentlicht in:Circulation (New York, N.Y.) N.Y.), 2020-05, Vol.141 (18), p.1452-1462
Hauptverfasser: Williams, Michelle C., Kwiecinski, Jacek, Doris, Mhairi, McElhinney, Priscilla, D’Souza, Michelle S., Cadet, Sebastien, Adamson, Philip D., Moss, Alastair J., Alam, Shirjel, Hunter, Amanda, Shah, Anoop S.V., Mills, Nicholas L., Pawade, Tania, Wang, Chengjia, Weir McCall, Jonathan, Bonnici-Mallia, Michael, Murrills, Christopher, Roditi, Giles, van Beek, Edwin J.R., Shaw, Leslee J., Nicol, Edward D., Berman, Daniel S., Slomka, Piotr J., Newby, David E., Dweck, Marc R., Dey, Damini
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Sprache:eng
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Zusammenfassung:The future risk of myocardial infarction is commonly assessed using cardiovascular risk scores, coronary artery calcium score, or coronary artery stenosis severity. We assessed whether noncalcified low-attenuation plaque burden on coronary CT angiography (CCTA) might be a better predictor of the future risk of myocardial infarction. In a post hoc analysis of a multicenter randomized controlled trial of CCTA in patients with stable chest pain, we investigated the association between the future risk of fatal or nonfatal myocardial infarction and low-attenuation plaque burden (% plaque to vessel volume), cardiovascular risk score, coronary artery calcium score or obstructive coronary artery stenoses. In 1769 patients (56% male; 58±10 years) followed up for a median 4.7 (interquartile interval, 4.0-5.7) years, low-attenuation plaque burden correlated weakly with cardiovascular risk score ( =0.34;
ISSN:0009-7322
1524-4539
1524-4539
DOI:10.1161/CIRCULATIONAHA.119.044720