Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide25-35-induced memory impairment in mice
In this study, experiments on amyloid β peptide 25-35 -induced mice were performed to provide in vivo evidence on the potential of the blood–brain barrier transportable soy dipeptide, Tyr-Pro, in combating memory impairment. We demonstrated for the first time that oral administration of Tyr-Pro (100...
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| Veröffentlicht in: | NPJ science of food 2020-05, Vol.4 (1), p.7-7, Article 7 |
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| container_title | NPJ science of food |
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| creator | Tanaka, Mitsuru Kiyohara, Hayato Yoshino, Atsuko Nakano, Akihiro Takata, Fuyuko Dohgu, Shinya Kataoka, Yasufumi Matsui, Toshiro |
| description | In this study, experiments on amyloid β peptide
25-35
-induced mice were performed to provide in vivo evidence on the potential of the blood–brain barrier transportable soy dipeptide, Tyr-Pro, in combating memory impairment. We demonstrated for the first time that oral administration of Tyr-Pro (100 mg/kg, twice a day) in mice for 16 days significantly improved impaired memory by spontaneous alternation and shortened step-through latency in amyloid β-induced mice. |
| doi_str_mv | 10.1038/s41538-020-0067-3 |
| format | Article |
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| subjects | 631/45/611 692/700/2814 Amyloid Blood-brain barrier Brief Communication Chemistry Chemistry and Materials Science Chemistry/Food Science Food Microbiology Food Science Impairment In vivo methods and tests Latency Nutrition Oral administration Spontaneous alternation |
| title | Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide25-35-induced memory impairment in mice |
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