COVID-19: Pandemic Contingency Planning for the Allergy and Immunology Clinic

In the event of a global infectious pandemic, drastic measures may be needed that limit or require adjustment of ambulatory allergy services. However, no rationale for how to prioritize service shut down and patient care exists. A consensus-based ad-hoc expert panel of allergy/immunology specialists...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The journal of allergy and clinical immunology in practice (Cambridge, MA) MA), 2020-05, Vol.8 (5), p.1477-1488.e5
Hauptverfasser: Shaker, Marcus S., Oppenheimer, John, Grayson, Mitchell, Stukus, David, Hartog, Nicholas, Hsieh, Elena W.Y., Rider, Nicholas, Dutmer, Cullen M., Vander Leek, Timothy K., Kim, Harold, Chan, Edmond S., Mack, Doug, Ellis, Anne K., Lang, David, Lieberman, Jay, Fleischer, David, Golden, David B.K., Wallace, Dana, Portnoy, Jay, Mosnaim, Giselle, Greenhawt, Matthew
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1488.e5
container_issue 5
container_start_page 1477
container_title The journal of allergy and clinical immunology in practice (Cambridge, MA)
container_volume 8
creator Shaker, Marcus S.
Oppenheimer, John
Grayson, Mitchell
Stukus, David
Hartog, Nicholas
Hsieh, Elena W.Y.
Rider, Nicholas
Dutmer, Cullen M.
Vander Leek, Timothy K.
Kim, Harold
Chan, Edmond S.
Mack, Doug
Ellis, Anne K.
Lang, David
Lieberman, Jay
Fleischer, David
Golden, David B.K.
Wallace, Dana
Portnoy, Jay
Mosnaim, Giselle
Greenhawt, Matthew
description In the event of a global infectious pandemic, drastic measures may be needed that limit or require adjustment of ambulatory allergy services. However, no rationale for how to prioritize service shut down and patient care exists. A consensus-based ad-hoc expert panel of allergy/immunology specialists from the United States and Canada developed a service and patient prioritization schematic to temporarily triage allergy/immunology services. Recommendations and feedback were developed iteratively, using an adapted modified Delphi methodology to achieve consensus. During the ongoing pandemic while social distancing is being encouraged, most allergy/immunology care could be postponed/delayed or handled through virtual care. With the exception of many patients with primary immunodeficiency, patients on venom immunotherapy, and patients with asthma of a certain severity, there is limited need for face-to-face visits under such conditions. These suggestions are intended to help provide a logical approach to quickly adjust service to mitigate risk to both medical staff and patients. Importantly, individual community circumstances may be unique and require contextual consideration. The decision to enact any of these measures rests with the judgment of each clinician and individual health care system. Pandemics are unanticipated, and enforced social distancing/quarantining is highly unusual. This expert panel consensus document offers a prioritization rational to help guide decision making when such situations arise and an allergist/immunologist is forced to reduce services or makes the decision on his or her own to do so.
doi_str_mv 10.1016/j.jaip.2020.03.012
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7195089</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2213219820302531</els_id><sourcerecordid>2384844696</sourcerecordid><originalsourceid>FETCH-LOGICAL-c521t-5eb04554950286fdc7b2fb1b157f55550d173482d830cd1bad868ad1864601143</originalsourceid><addsrcrecordid>eNp9UU1r3DAQFaWlCUn-QA_Fx17sakayLZdSCO7XQkpySHoVsiRvtNjSVvIG9t9XyyahvWQu0jBv3sy8R8g7oBVQaD5uqo1y2wop0oqyigK-IqeIwEpECq-f_tCJE3KR0obmENBSTt-SE4aIHBmekl_99e_V1xK6T8WN8sbOThd98Ivza-v1vriZlPc5KcYQi-XeFpfTZON6X2RwsZrnnQ9TyGk_Oe_0OXkzqinZi8f3jNx9_3bb_yyvrn-s-surUtcIS1nbgfK65l1NUTSj0e2A4wAD1O1Y56AGWsYFGsGoNjAoIxqhDIiGNxSAszPy5ci73Q2zNdr6JapJbqObVdzLoJz8v-LdvVyHB9lCnim6TPDhkSCGPzubFjm7pO2Ur7VhlyQywQXnTddkKB6hOoaUoh2fxwCVByvkRh6skAcrJGUyW5Gb3v-74HPLk_AZ8PkIsFmmB2ejTNplxa1x0epFmuBe4v8LXj2Ylg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2384844696</pqid></control><display><type>article</type><title>COVID-19: Pandemic Contingency Planning for the Allergy and Immunology Clinic</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Shaker, Marcus S. ; Oppenheimer, John ; Grayson, Mitchell ; Stukus, David ; Hartog, Nicholas ; Hsieh, Elena W.Y. ; Rider, Nicholas ; Dutmer, Cullen M. ; Vander Leek, Timothy K. ; Kim, Harold ; Chan, Edmond S. ; Mack, Doug ; Ellis, Anne K. ; Lang, David ; Lieberman, Jay ; Fleischer, David ; Golden, David B.K. ; Wallace, Dana ; Portnoy, Jay ; Mosnaim, Giselle ; Greenhawt, Matthew</creator><creatorcontrib>Shaker, Marcus S. ; Oppenheimer, John ; Grayson, Mitchell ; Stukus, David ; Hartog, Nicholas ; Hsieh, Elena W.Y. ; Rider, Nicholas ; Dutmer, Cullen M. ; Vander Leek, Timothy K. ; Kim, Harold ; Chan, Edmond S. ; Mack, Doug ; Ellis, Anne K. ; Lang, David ; Lieberman, Jay ; Fleischer, David ; Golden, David B.K. ; Wallace, Dana ; Portnoy, Jay ; Mosnaim, Giselle ; Greenhawt, Matthew</creatorcontrib><description>In the event of a global infectious pandemic, drastic measures may be needed that limit or require adjustment of ambulatory allergy services. However, no rationale for how to prioritize service shut down and patient care exists. A consensus-based ad-hoc expert panel of allergy/immunology specialists from the United States and Canada developed a service and patient prioritization schematic to temporarily triage allergy/immunology services. Recommendations and feedback were developed iteratively, using an adapted modified Delphi methodology to achieve consensus. During the ongoing pandemic while social distancing is being encouraged, most allergy/immunology care could be postponed/delayed or handled through virtual care. With the exception of many patients with primary immunodeficiency, patients on venom immunotherapy, and patients with asthma of a certain severity, there is limited need for face-to-face visits under such conditions. These suggestions are intended to help provide a logical approach to quickly adjust service to mitigate risk to both medical staff and patients. Importantly, individual community circumstances may be unique and require contextual consideration. The decision to enact any of these measures rests with the judgment of each clinician and individual health care system. Pandemics are unanticipated, and enforced social distancing/quarantining is highly unusual. This expert panel consensus document offers a prioritization rational to help guide decision making when such situations arise and an allergist/immunologist is forced to reduce services or makes the decision on his or her own to do so.</description><identifier>ISSN: 2213-2198</identifier><identifier>EISSN: 2213-2201</identifier><identifier>DOI: 10.1016/j.jaip.2020.03.012</identifier><identifier>PMID: 32224232</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Allergic rhinitis ; Allergy ; Allergy and Immunology ; Allergy immunotherapy ; Ambulatory Care Facilities - organization &amp; administration ; Angioedema ; Asthma ; Atopic dermatitis ; Coronavirus Infections - epidemiology ; Coronavirus Infections - prevention &amp; control ; COVID-19 ; Food allergy ; Humans ; Pandemics - prevention &amp; control ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - prevention &amp; control ; Primary immunodeficiency ; SARS-CoV-2 ; Telemedicine ; Urticaria ; Venom allergy</subject><ispartof>The journal of allergy and clinical immunology in practice (Cambridge, MA), 2020-05, Vol.8 (5), p.1477-1488.e5</ispartof><rights>2020 American Academy of Allergy, Asthma &amp; Immunology</rights><rights>Copyright © 2020 American Academy of Allergy, Asthma &amp; Immunology. Published by Elsevier Inc. All rights reserved.</rights><rights>2020 American Academy of Allergy, Asthma &amp; Immunology. 2020 American Academy of Allergy, Asthma &amp; Immunology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-5eb04554950286fdc7b2fb1b157f55550d173482d830cd1bad868ad1864601143</citedby><cites>FETCH-LOGICAL-c521t-5eb04554950286fdc7b2fb1b157f55550d173482d830cd1bad868ad1864601143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32224232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shaker, Marcus S.</creatorcontrib><creatorcontrib>Oppenheimer, John</creatorcontrib><creatorcontrib>Grayson, Mitchell</creatorcontrib><creatorcontrib>Stukus, David</creatorcontrib><creatorcontrib>Hartog, Nicholas</creatorcontrib><creatorcontrib>Hsieh, Elena W.Y.</creatorcontrib><creatorcontrib>Rider, Nicholas</creatorcontrib><creatorcontrib>Dutmer, Cullen M.</creatorcontrib><creatorcontrib>Vander Leek, Timothy K.</creatorcontrib><creatorcontrib>Kim, Harold</creatorcontrib><creatorcontrib>Chan, Edmond S.</creatorcontrib><creatorcontrib>Mack, Doug</creatorcontrib><creatorcontrib>Ellis, Anne K.</creatorcontrib><creatorcontrib>Lang, David</creatorcontrib><creatorcontrib>Lieberman, Jay</creatorcontrib><creatorcontrib>Fleischer, David</creatorcontrib><creatorcontrib>Golden, David B.K.</creatorcontrib><creatorcontrib>Wallace, Dana</creatorcontrib><creatorcontrib>Portnoy, Jay</creatorcontrib><creatorcontrib>Mosnaim, Giselle</creatorcontrib><creatorcontrib>Greenhawt, Matthew</creatorcontrib><title>COVID-19: Pandemic Contingency Planning for the Allergy and Immunology Clinic</title><title>The journal of allergy and clinical immunology in practice (Cambridge, MA)</title><addtitle>J Allergy Clin Immunol Pract</addtitle><description>In the event of a global infectious pandemic, drastic measures may be needed that limit or require adjustment of ambulatory allergy services. However, no rationale for how to prioritize service shut down and patient care exists. A consensus-based ad-hoc expert panel of allergy/immunology specialists from the United States and Canada developed a service and patient prioritization schematic to temporarily triage allergy/immunology services. Recommendations and feedback were developed iteratively, using an adapted modified Delphi methodology to achieve consensus. During the ongoing pandemic while social distancing is being encouraged, most allergy/immunology care could be postponed/delayed or handled through virtual care. With the exception of many patients with primary immunodeficiency, patients on venom immunotherapy, and patients with asthma of a certain severity, there is limited need for face-to-face visits under such conditions. These suggestions are intended to help provide a logical approach to quickly adjust service to mitigate risk to both medical staff and patients. Importantly, individual community circumstances may be unique and require contextual consideration. The decision to enact any of these measures rests with the judgment of each clinician and individual health care system. Pandemics are unanticipated, and enforced social distancing/quarantining is highly unusual. This expert panel consensus document offers a prioritization rational to help guide decision making when such situations arise and an allergist/immunologist is forced to reduce services or makes the decision on his or her own to do so.</description><subject>Allergic rhinitis</subject><subject>Allergy</subject><subject>Allergy and Immunology</subject><subject>Allergy immunotherapy</subject><subject>Ambulatory Care Facilities - organization &amp; administration</subject><subject>Angioedema</subject><subject>Asthma</subject><subject>Atopic dermatitis</subject><subject>Coronavirus Infections - epidemiology</subject><subject>Coronavirus Infections - prevention &amp; control</subject><subject>COVID-19</subject><subject>Food allergy</subject><subject>Humans</subject><subject>Pandemics - prevention &amp; control</subject><subject>Pneumonia, Viral - epidemiology</subject><subject>Pneumonia, Viral - prevention &amp; control</subject><subject>Primary immunodeficiency</subject><subject>SARS-CoV-2</subject><subject>Telemedicine</subject><subject>Urticaria</subject><subject>Venom allergy</subject><issn>2213-2198</issn><issn>2213-2201</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1r3DAQFaWlCUn-QA_Fx17sakayLZdSCO7XQkpySHoVsiRvtNjSVvIG9t9XyyahvWQu0jBv3sy8R8g7oBVQaD5uqo1y2wop0oqyigK-IqeIwEpECq-f_tCJE3KR0obmENBSTt-SE4aIHBmekl_99e_V1xK6T8WN8sbOThd98Ivza-v1vriZlPc5KcYQi-XeFpfTZON6X2RwsZrnnQ9TyGk_Oe_0OXkzqinZi8f3jNx9_3bb_yyvrn-s-surUtcIS1nbgfK65l1NUTSj0e2A4wAD1O1Y56AGWsYFGsGoNjAoIxqhDIiGNxSAszPy5ci73Q2zNdr6JapJbqObVdzLoJz8v-LdvVyHB9lCnim6TPDhkSCGPzubFjm7pO2Ur7VhlyQywQXnTddkKB6hOoaUoh2fxwCVByvkRh6skAcrJGUyW5Gb3v-74HPLk_AZ8PkIsFmmB2ejTNplxa1x0epFmuBe4v8LXj2Ylg</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Shaker, Marcus S.</creator><creator>Oppenheimer, John</creator><creator>Grayson, Mitchell</creator><creator>Stukus, David</creator><creator>Hartog, Nicholas</creator><creator>Hsieh, Elena W.Y.</creator><creator>Rider, Nicholas</creator><creator>Dutmer, Cullen M.</creator><creator>Vander Leek, Timothy K.</creator><creator>Kim, Harold</creator><creator>Chan, Edmond S.</creator><creator>Mack, Doug</creator><creator>Ellis, Anne K.</creator><creator>Lang, David</creator><creator>Lieberman, Jay</creator><creator>Fleischer, David</creator><creator>Golden, David B.K.</creator><creator>Wallace, Dana</creator><creator>Portnoy, Jay</creator><creator>Mosnaim, Giselle</creator><creator>Greenhawt, Matthew</creator><general>Elsevier Inc</general><general>American Academy of Allergy, Asthma &amp; Immunology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200501</creationdate><title>COVID-19: Pandemic Contingency Planning for the Allergy and Immunology Clinic</title><author>Shaker, Marcus S. ; Oppenheimer, John ; Grayson, Mitchell ; Stukus, David ; Hartog, Nicholas ; Hsieh, Elena W.Y. ; Rider, Nicholas ; Dutmer, Cullen M. ; Vander Leek, Timothy K. ; Kim, Harold ; Chan, Edmond S. ; Mack, Doug ; Ellis, Anne K. ; Lang, David ; Lieberman, Jay ; Fleischer, David ; Golden, David B.K. ; Wallace, Dana ; Portnoy, Jay ; Mosnaim, Giselle ; Greenhawt, Matthew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-5eb04554950286fdc7b2fb1b157f55550d173482d830cd1bad868ad1864601143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Allergic rhinitis</topic><topic>Allergy</topic><topic>Allergy and Immunology</topic><topic>Allergy immunotherapy</topic><topic>Ambulatory Care Facilities - organization &amp; administration</topic><topic>Angioedema</topic><topic>Asthma</topic><topic>Atopic dermatitis</topic><topic>Coronavirus Infections - epidemiology</topic><topic>Coronavirus Infections - prevention &amp; control</topic><topic>COVID-19</topic><topic>Food allergy</topic><topic>Humans</topic><topic>Pandemics - prevention &amp; control</topic><topic>Pneumonia, Viral - epidemiology</topic><topic>Pneumonia, Viral - prevention &amp; control</topic><topic>Primary immunodeficiency</topic><topic>SARS-CoV-2</topic><topic>Telemedicine</topic><topic>Urticaria</topic><topic>Venom allergy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shaker, Marcus S.</creatorcontrib><creatorcontrib>Oppenheimer, John</creatorcontrib><creatorcontrib>Grayson, Mitchell</creatorcontrib><creatorcontrib>Stukus, David</creatorcontrib><creatorcontrib>Hartog, Nicholas</creatorcontrib><creatorcontrib>Hsieh, Elena W.Y.</creatorcontrib><creatorcontrib>Rider, Nicholas</creatorcontrib><creatorcontrib>Dutmer, Cullen M.</creatorcontrib><creatorcontrib>Vander Leek, Timothy K.</creatorcontrib><creatorcontrib>Kim, Harold</creatorcontrib><creatorcontrib>Chan, Edmond S.</creatorcontrib><creatorcontrib>Mack, Doug</creatorcontrib><creatorcontrib>Ellis, Anne K.</creatorcontrib><creatorcontrib>Lang, David</creatorcontrib><creatorcontrib>Lieberman, Jay</creatorcontrib><creatorcontrib>Fleischer, David</creatorcontrib><creatorcontrib>Golden, David B.K.</creatorcontrib><creatorcontrib>Wallace, Dana</creatorcontrib><creatorcontrib>Portnoy, Jay</creatorcontrib><creatorcontrib>Mosnaim, Giselle</creatorcontrib><creatorcontrib>Greenhawt, Matthew</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of allergy and clinical immunology in practice (Cambridge, MA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shaker, Marcus S.</au><au>Oppenheimer, John</au><au>Grayson, Mitchell</au><au>Stukus, David</au><au>Hartog, Nicholas</au><au>Hsieh, Elena W.Y.</au><au>Rider, Nicholas</au><au>Dutmer, Cullen M.</au><au>Vander Leek, Timothy K.</au><au>Kim, Harold</au><au>Chan, Edmond S.</au><au>Mack, Doug</au><au>Ellis, Anne K.</au><au>Lang, David</au><au>Lieberman, Jay</au><au>Fleischer, David</au><au>Golden, David B.K.</au><au>Wallace, Dana</au><au>Portnoy, Jay</au><au>Mosnaim, Giselle</au><au>Greenhawt, Matthew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COVID-19: Pandemic Contingency Planning for the Allergy and Immunology Clinic</atitle><jtitle>The journal of allergy and clinical immunology in practice (Cambridge, MA)</jtitle><addtitle>J Allergy Clin Immunol Pract</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>8</volume><issue>5</issue><spage>1477</spage><epage>1488.e5</epage><pages>1477-1488.e5</pages><issn>2213-2198</issn><eissn>2213-2201</eissn><abstract>In the event of a global infectious pandemic, drastic measures may be needed that limit or require adjustment of ambulatory allergy services. However, no rationale for how to prioritize service shut down and patient care exists. A consensus-based ad-hoc expert panel of allergy/immunology specialists from the United States and Canada developed a service and patient prioritization schematic to temporarily triage allergy/immunology services. Recommendations and feedback were developed iteratively, using an adapted modified Delphi methodology to achieve consensus. During the ongoing pandemic while social distancing is being encouraged, most allergy/immunology care could be postponed/delayed or handled through virtual care. With the exception of many patients with primary immunodeficiency, patients on venom immunotherapy, and patients with asthma of a certain severity, there is limited need for face-to-face visits under such conditions. These suggestions are intended to help provide a logical approach to quickly adjust service to mitigate risk to both medical staff and patients. Importantly, individual community circumstances may be unique and require contextual consideration. The decision to enact any of these measures rests with the judgment of each clinician and individual health care system. Pandemics are unanticipated, and enforced social distancing/quarantining is highly unusual. This expert panel consensus document offers a prioritization rational to help guide decision making when such situations arise and an allergist/immunologist is forced to reduce services or makes the decision on his or her own to do so.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32224232</pmid><doi>10.1016/j.jaip.2020.03.012</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2213-2198
ispartof The journal of allergy and clinical immunology in practice (Cambridge, MA), 2020-05, Vol.8 (5), p.1477-1488.e5
issn 2213-2198
2213-2201
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7195089
source MEDLINE; Alma/SFX Local Collection
subjects Allergic rhinitis
Allergy
Allergy and Immunology
Allergy immunotherapy
Ambulatory Care Facilities - organization & administration
Angioedema
Asthma
Atopic dermatitis
Coronavirus Infections - epidemiology
Coronavirus Infections - prevention & control
COVID-19
Food allergy
Humans
Pandemics - prevention & control
Pneumonia, Viral - epidemiology
Pneumonia, Viral - prevention & control
Primary immunodeficiency
SARS-CoV-2
Telemedicine
Urticaria
Venom allergy
title COVID-19: Pandemic Contingency Planning for the Allergy and Immunology Clinic
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T21%3A53%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=COVID-19:%20Pandemic%20Contingency%20Planning%20for%20the%20Allergy%20and%20Immunology%20Clinic&rft.jtitle=The%20journal%20of%20allergy%20and%20clinical%20immunology%20in%20practice%20(Cambridge,%20MA)&rft.au=Shaker,%20Marcus%20S.&rft.date=2020-05-01&rft.volume=8&rft.issue=5&rft.spage=1477&rft.epage=1488.e5&rft.pages=1477-1488.e5&rft.issn=2213-2198&rft.eissn=2213-2201&rft_id=info:doi/10.1016/j.jaip.2020.03.012&rft_dat=%3Cproquest_pubme%3E2384844696%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2384844696&rft_id=info:pmid/32224232&rft_els_id=S2213219820302531&rfr_iscdi=true