The pathogenesis and treatment of the `Cytokine Storm' in COVID-19
Cytokine storm is a general term applied to maladaptive cytokine release in response to infection and other stimuli. The pathogenesis is complex but includes loss of regulatory control of proinflammatory cytokine production, both at local and systemic levels. The disease progresses rapidly, and the...
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| Veröffentlicht in: | The Journal of infection 2020-06, Vol.80 (6), p.607-613 |
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| container_title | The Journal of infection |
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| creator | Ye, Qing Wang, Bili Mao, Jianhua |
| description | Cytokine storm is a general term applied to maladaptive cytokine release in response to infection and other stimuli. The pathogenesis is complex but includes loss of regulatory control of proinflammatory cytokine production, both at local and systemic levels. The disease progresses rapidly, and the mortality is high. Some evidence shows that, during the coronavirus disease 2019 (COVID-19) epidemic, severe deterioration in some patients has been closely associated with dysregulated and excessive cytokine release. This article reviews what we know of the mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in an attempt to provide some background to inform future guidance for clinical treatment. |
| doi_str_mv | 10.1016/j.jinf.2020.03.037 |
| format | Article |
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| ispartof | The Journal of infection, 2020-06, Vol.80 (6), p.607-613 |
| issn | 0163-4453 1532-2742 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 2019-nCoV Anti-Inflammatory Agents - therapeutic use Betacoronavirus - immunology Coronavirus Coronavirus Infections - complications Coronavirus Infections - physiopathology Coronavirus Infections - therapy COVID-19 Critical Illness - therapy Cytokine Release Syndrome - etiology Cytokine Release Syndrome - physiopathology Cytokine Release Syndrome - therapy Cytokine storm Humans Immunomodulation Pandemics Pneumonia, Viral - complications Pneumonia, Viral - physiopathology Pneumonia, Viral - therapy SARS-CoV-2 |
| title | The pathogenesis and treatment of the `Cytokine Storm' in COVID-19 |
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