NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback

•NMDA receptor channel blockers induced stronger neuronal oscillations in GluN2C knockout mice.•NMDA receptor channel blockers induced weaker neuronal oscillations in GluN2D knockout mice.•NVP-AAM077 and Ro 25-6981induced oscillations appear to be unchanged in GluN2C and GluN2D knockouts.•GluN2C/D-c...

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Veröffentlicht in:	Brain research 2020-01, Vol.1727, p.146571-146571, Article 146571
Hauptverfasser:	Mao, Zhihao, He, Shengxi, Mesnard, Christopher, Synowicki, Paul, Zhang, Yuning, Chung, Lucy, Wiesman, Alex I., Wilson, Tony W., Monaghan, Daniel T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocyte Electrocorticography Excitatory Amino Acid Antagonists - pharmacology Interneuron Ketamine Mice Mice, Knockout Neurofeedback - physiology Neurons - drug effects Neurons - physiology NMDA receptors Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - physiology Schizophrenia
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