Targeted analysis of polymorphic loci from low-coverage shotgun sequence data allows accurate genotyping of HLA genes in historical human populations

The highly polymorphic human leukocyte antigen (HLA) plays a crucial role in adaptive immunity and is associated with various complex diseases. Accurate analysis of HLA genes using ancient DNA (aDNA) data is crucial for understanding their role in human adaptation to pathogens. Here, we describe the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2020-04, Vol.10 (1), p.7339-7339, Article 7339
Hauptverfasser:	Pierini, Federica, Nutsua, Marcel, Böhme, Lisa, Özer, Onur, Bonczarowska, Joanna, Susat, Julian, Franke, Andre, Nebel, Almut, Krause-Kyora, Ben, Lenz, Tobias L.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/181/2474 631/181/414 631/181/457 631/208/182 631/208/248 631/208/514 631/208/721 631/208/728 631/250/2152 Adaptive immunity Alleles Denmark DNA, Ancient - analysis Genetic Markers Genetics, Population Genome, Human Genomes Genotype Genotyping Haplotypes High-Throughput Nucleotide Sequencing Histocompatibility antigen HLA Histocompatibility Antigens Class II - genetics HLA Antigens - genetics Human populations Humanities and Social Sciences Humans multidisciplinary Pattern Recognition, Automated Polymorphism, Single Nucleotide Science Science (multidisciplinary)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!