Eomes identifies thymic precursors of self-specific memory-phenotype CD8+ T cells

Unprimed mice harbor a substantial population of ‘memory-phenotype’ CD8 + T cells (CD8-MP cells) that exhibit hallmarks of activation and innate-like functional properties. Due to the lack of faithful markers to distinguish CD8-MP cells from bona fide CD8 + memory T cells, the developmental origins...

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Veröffentlicht in:	Nature immunology 2020-05, Vol.21 (5), p.567-577
Hauptverfasser:	Miller, Christine H., Klawon, David E. J., Zeng, Sharon, Lee, Victoria, Socci, Nicholas D., Savage, Peter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2152/1566/1571 631/250/2152/1566/2493 631/250/580 Animals Antigens Antitumor activity Autoantigens - immunology Biomedical and Life Sciences Biomedicine CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell Differentiation Clonal Selection, Antigen-Mediated Clone Cells Genotype & phenotype Immunologic Memory Immunological memory Immunology Immunotherapy Infectious Diseases Ligands Lymphocytes Lymphocytes T Male Memory cells Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic PD-1 protein Phenotypes Programmed Cell Death 1 Receptor - metabolism Prostate Prostate cancer Prostatic Neoplasms - immunology Receptors, Antigen, T-Cell - genetics T cell receptors T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism Thymus Thymus gland Thymus Gland - physiology Up-Regulation
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