Chronic heat treatment positively impacts metabolic profile of ovariectomized rats: association with heat shock response pathways
Low estrogen levels may predispose women to increased bodyweight and dyslipidemia. Previous studies from our laboratory suggest an involvement of depressed heat shock response (HSR) in this scenario because estrogen potently stimulates HSR. As heat treatment induces the expression of the anti-inflam...
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| creator | Lissarassa, Yana Picinin Sandri Vincensi, Carolain Felipin Costa-Beber, Lílian Corrêa dos Santos, Analú Bender Goettems-Fiorin, Pauline Brendler dos Santos, Jaíne Borges Donato, Yohanna Hannnah Wildner, Guilherme de Bittencourt Júnior, Paulo Ivo Homem Frizzo, Matias Nunes Heck, Thiago Gomes Ludwig, Mirna Stela |
| description | Low estrogen levels may predispose women to increased bodyweight and dyslipidemia. Previous studies from our laboratory suggest an involvement of depressed heat shock response (HSR) in this scenario because estrogen potently stimulates HSR. As heat treatment induces the expression of the anti-inflammatory heat shock proteins of the 70-kDa family (HSP70) and its accompanying HSR, we aimed to investigate whether chronic heat treatment promotes beneficial effects on biometric, lipid profile, oxidative stress, and HSR in ovariectomized rats. Wistar adult female rats (n = 32) were divided into four groups: control (C, n = 7), ovariectomized (OVX, n = 9), heat-treated (HT, n = 9), and heat-treated ovariectomized rats (OVX+HT, n = 7). HTand OVX+HT rats were anesthetized and submitted to heat treatment (once a week for 12 weeks) in a water bath (41 °C) to increase rats’ rectal temperature up to 41 °C for 15 min, while C and OVX animals were submitted to a 36 °C water bath. HT attenuated the weight gain induced by OVX and increased HDL cholesterol and triglyceride serum levels. Also, OVX rats showed increased total cholesterol and LDL cholesterol levels that were not influenced by HT. Interestingly, it was found that an overall trend for HT to decrease tissue catalase and superoxide dismutase antioxidant activities was paralleled by a decrease in malondialdehyde levels (indicative of lower lipoperoxidation), especially in the skeletal muscle. Surprisingly, OVX was not able to depress intracellular HSP70 expression in the skeletal muscle, as expected, and this remained unchanged with HT. However, chronic HT did enhance intracellular HSP70 contents in white adipose tissue of OVX animals. As both glucose and insulin tolerance tests were not affected by OVX, which was not modified by HT, we suppose that estrogen absence alone is not sufficient to determine a state of insulin resistance associated with low intramuscular HSP70 content. |
| doi_str_mv | 10.1007/s12192-020-01087-z |
| format | Article |
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Previous studies from our laboratory suggest an involvement of depressed heat shock response (HSR) in this scenario because estrogen potently stimulates HSR. As heat treatment induces the expression of the anti-inflammatory heat shock proteins of the 70-kDa family (HSP70) and its accompanying HSR, we aimed to investigate whether chronic heat treatment promotes beneficial effects on biometric, lipid profile, oxidative stress, and HSR in ovariectomized rats. Wistar adult female rats (n = 32) were divided into four groups: control (C, n = 7), ovariectomized (OVX, n = 9), heat-treated (HT, n = 9), and heat-treated ovariectomized rats (OVX+HT, n = 7). HTand OVX+HT rats were anesthetized and submitted to heat treatment (once a week for 12 weeks) in a water bath (41 °C) to increase rats’ rectal temperature up to 41 °C for 15 min, while C and OVX animals were submitted to a 36 °C water bath. HT attenuated the weight gain induced by OVX and increased HDL cholesterol and triglyceride serum levels. Also, OVX rats showed increased total cholesterol and LDL cholesterol levels that were not influenced by HT. Interestingly, it was found that an overall trend for HT to decrease tissue catalase and superoxide dismutase antioxidant activities was paralleled by a decrease in malondialdehyde levels (indicative of lower lipoperoxidation), especially in the skeletal muscle. Surprisingly, OVX was not able to depress intracellular HSP70 expression in the skeletal muscle, as expected, and this remained unchanged with HT. However, chronic HT did enhance intracellular HSP70 contents in white adipose tissue of OVX animals. As both glucose and insulin tolerance tests were not affected by OVX, which was not modified by HT, we suppose that estrogen absence alone is not sufficient to determine a state of insulin resistance associated with low intramuscular HSP70 content.</description><identifier>ISSN: 1355-8145</identifier><identifier>EISSN: 1466-1268</identifier><identifier>DOI: 10.1007/s12192-020-01087-z</identifier><identifier>PMID: 32215846</identifier><language>eng</language><publisher>Dordrecht: Springer Science + Business Media</publisher><subject>Adipose tissue ; Adipose Tissue, White - metabolism ; Animal tissues ; Animals ; Antioxidants ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Body weight gain ; Cancer Research ; Catalase ; Cell Biology ; Cholesterol ; Dyslipidemia ; Estrogens ; Female ; Glucose tolerance ; Glucose Tolerance Test ; Heat shock proteins ; Heat treatment ; Heat treatments ; Heat-Shock Response ; High density lipoprotein ; Hot Temperature ; HSP70 Heat-Shock Proteins - blood ; HSP70 Heat-Shock Proteins - metabolism ; Hsp70 protein ; Immunology ; Inflammation ; Insulin ; Insulin resistance ; Intracellular ; Lipid Metabolism ; Lipids ; Lipids - blood ; Low density lipoprotein ; Malondialdehyde ; Muscles ; Muscles - metabolism ; Musculoskeletal system ; Neurosciences ; ORIGINAL PAPER ; Ovariectomy ; Oxidative Stress ; Rats, Wistar ; Rodents ; Serum levels ; Skeletal muscle ; Superoxide dismutase ; Triglycerides ; Water baths</subject><ispartof>Cell stress & chaperones, 2020-05, Vol.25 (3), p.467-479</ispartof><rights>Cell Stress Society International 2020</rights><rights>Cell Stress Society International 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-e99dbb226c98e772342f9a7d8529dd1ac02047d2af3ecbd7376bba865db44b993</citedby><cites>FETCH-LOGICAL-c496t-e99dbb226c98e772342f9a7d8529dd1ac02047d2af3ecbd7376bba865db44b993</cites><orcidid>0000-0003-0300-1511 ; 0000-0002-1242-5423</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/48724160$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/48724160$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,41488,42557,51319,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32215846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lissarassa, Yana Picinin Sandri</creatorcontrib><creatorcontrib>Vincensi, Carolain Felipin</creatorcontrib><creatorcontrib>Costa-Beber, Lílian Corrêa</creatorcontrib><creatorcontrib>dos Santos, Analú Bender</creatorcontrib><creatorcontrib>Goettems-Fiorin, Pauline Brendler</creatorcontrib><creatorcontrib>dos Santos, Jaíne Borges</creatorcontrib><creatorcontrib>Donato, Yohanna Hannnah</creatorcontrib><creatorcontrib>Wildner, Guilherme</creatorcontrib><creatorcontrib>de Bittencourt Júnior, Paulo Ivo Homem</creatorcontrib><creatorcontrib>Frizzo, Matias Nunes</creatorcontrib><creatorcontrib>Heck, Thiago Gomes</creatorcontrib><creatorcontrib>Ludwig, Mirna Stela</creatorcontrib><title>Chronic heat treatment positively impacts metabolic profile of ovariectomized rats: association with heat shock response pathways</title><title>Cell stress & chaperones</title><addtitle>Cell Stress and Chaperones</addtitle><addtitle>Cell Stress Chaperones</addtitle><description>Low estrogen levels may predispose women to increased bodyweight and dyslipidemia. Previous studies from our laboratory suggest an involvement of depressed heat shock response (HSR) in this scenario because estrogen potently stimulates HSR. As heat treatment induces the expression of the anti-inflammatory heat shock proteins of the 70-kDa family (HSP70) and its accompanying HSR, we aimed to investigate whether chronic heat treatment promotes beneficial effects on biometric, lipid profile, oxidative stress, and HSR in ovariectomized rats. Wistar adult female rats (n = 32) were divided into four groups: control (C, n = 7), ovariectomized (OVX, n = 9), heat-treated (HT, n = 9), and heat-treated ovariectomized rats (OVX+HT, n = 7). HTand OVX+HT rats were anesthetized and submitted to heat treatment (once a week for 12 weeks) in a water bath (41 °C) to increase rats’ rectal temperature up to 41 °C for 15 min, while C and OVX animals were submitted to a 36 °C water bath. HT attenuated the weight gain induced by OVX and increased HDL cholesterol and triglyceride serum levels. Also, OVX rats showed increased total cholesterol and LDL cholesterol levels that were not influenced by HT. Interestingly, it was found that an overall trend for HT to decrease tissue catalase and superoxide dismutase antioxidant activities was paralleled by a decrease in malondialdehyde levels (indicative of lower lipoperoxidation), especially in the skeletal muscle. Surprisingly, OVX was not able to depress intracellular HSP70 expression in the skeletal muscle, as expected, and this remained unchanged with HT. However, chronic HT did enhance intracellular HSP70 contents in white adipose tissue of OVX animals. As both glucose and insulin tolerance tests were not affected by OVX, which was not modified by HT, we suppose that estrogen absence alone is not sufficient to determine a state of insulin resistance associated with low intramuscular HSP70 content.</description><subject>Adipose tissue</subject><subject>Adipose Tissue, White - metabolism</subject><subject>Animal tissues</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body weight gain</subject><subject>Cancer Research</subject><subject>Catalase</subject><subject>Cell Biology</subject><subject>Cholesterol</subject><subject>Dyslipidemia</subject><subject>Estrogens</subject><subject>Female</subject><subject>Glucose tolerance</subject><subject>Glucose Tolerance Test</subject><subject>Heat shock proteins</subject><subject>Heat treatment</subject><subject>Heat treatments</subject><subject>Heat-Shock Response</subject><subject>High density lipoprotein</subject><subject>Hot Temperature</subject><subject>HSP70 Heat-Shock Proteins - blood</subject><subject>HSP70 Heat-Shock Proteins - metabolism</subject><subject>Hsp70 protein</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Intracellular</subject><subject>Lipid Metabolism</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Low density lipoprotein</subject><subject>Malondialdehyde</subject><subject>Muscles</subject><subject>Muscles - metabolism</subject><subject>Musculoskeletal system</subject><subject>Neurosciences</subject><subject>ORIGINAL PAPER</subject><subject>Ovariectomy</subject><subject>Oxidative Stress</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Serum levels</subject><subject>Skeletal muscle</subject><subject>Superoxide dismutase</subject><subject>Triglycerides</subject><subject>Water baths</subject><issn>1355-8145</issn><issn>1466-1268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUlrHDEQhUVwiJfkDxgSGnLxpWNtreViCEM2MASCcxba2qOhu9WWNAOeXx857UycHHyRBPW9V_VUAJwj-AFByC8zwkjiFmLYQgQFb_cvwAmijLUIM3FU36TrWoFodwxOc97AKuIcvQLHBGPUCcpOwI_VOsUp2GbtdWlKqufop9LMMYcSdn64b8I4a1tyM_qiTRwqO6fYh8E3sW_iTqfgbYlj2HvXJF3ya_Cy10P2bx7vM_Dz86eb1df2-vuXb6uP162lkpXWS-mMwZhZKTznmFDcS82d6LB0Dmlbc1HusO6Jt8ZxwpkxWrDOGUqNlOQMXC2-89aM3tk6dtKDmlMYdbpXUQf1b2UKa3Ubd4rXX5MCVoOLR4MU77Y-FzWGbP0w6MnHbVaYCIoRIvSh1_v_0E3cpqnGq5RkElEiRaXwQtkUc06-PwyDoHpYmVpWpmo09Xtlal9F757GOEj-7KgCZAFyLU23Pv3t_azt20W1ySWmgysVHFPEIPkF1_-uAA</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Lissarassa, Yana Picinin Sandri</creator><creator>Vincensi, Carolain Felipin</creator><creator>Costa-Beber, Lílian Corrêa</creator><creator>dos Santos, Analú Bender</creator><creator>Goettems-Fiorin, Pauline Brendler</creator><creator>dos Santos, Jaíne Borges</creator><creator>Donato, Yohanna Hannnah</creator><creator>Wildner, Guilherme</creator><creator>de Bittencourt Júnior, Paulo Ivo Homem</creator><creator>Frizzo, Matias Nunes</creator><creator>Heck, Thiago Gomes</creator><creator>Ludwig, Mirna Stela</creator><general>Springer Science + Business Media</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0300-1511</orcidid><orcidid>https://orcid.org/0000-0002-1242-5423</orcidid></search><sort><creationdate>20200501</creationdate><title>Chronic heat treatment positively impacts metabolic profile of ovariectomized rats</title><author>Lissarassa, Yana Picinin Sandri ; Vincensi, Carolain Felipin ; Costa-Beber, Lílian Corrêa ; dos Santos, Analú Bender ; Goettems-Fiorin, Pauline Brendler ; dos Santos, Jaíne Borges ; Donato, Yohanna Hannnah ; Wildner, Guilherme ; de Bittencourt Júnior, Paulo Ivo Homem ; Frizzo, Matias Nunes ; Heck, Thiago Gomes ; Ludwig, Mirna Stela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-e99dbb226c98e772342f9a7d8529dd1ac02047d2af3ecbd7376bba865db44b993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue, White - metabolism</topic><topic>Animal tissues</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body weight gain</topic><topic>Cancer Research</topic><topic>Catalase</topic><topic>Cell Biology</topic><topic>Cholesterol</topic><topic>Dyslipidemia</topic><topic>Estrogens</topic><topic>Female</topic><topic>Glucose tolerance</topic><topic>Glucose Tolerance Test</topic><topic>Heat shock proteins</topic><topic>Heat treatment</topic><topic>Heat treatments</topic><topic>Heat-Shock Response</topic><topic>High density lipoprotein</topic><topic>Hot Temperature</topic><topic>HSP70 Heat-Shock Proteins - blood</topic><topic>HSP70 Heat-Shock Proteins - metabolism</topic><topic>Hsp70 protein</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Intracellular</topic><topic>Lipid Metabolism</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Low density lipoprotein</topic><topic>Malondialdehyde</topic><topic>Muscles</topic><topic>Muscles - metabolism</topic><topic>Musculoskeletal system</topic><topic>Neurosciences</topic><topic>ORIGINAL PAPER</topic><topic>Ovariectomy</topic><topic>Oxidative Stress</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Serum levels</topic><topic>Skeletal muscle</topic><topic>Superoxide dismutase</topic><topic>Triglycerides</topic><topic>Water baths</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lissarassa, Yana Picinin Sandri</creatorcontrib><creatorcontrib>Vincensi, Carolain Felipin</creatorcontrib><creatorcontrib>Costa-Beber, Lílian Corrêa</creatorcontrib><creatorcontrib>dos Santos, Analú Bender</creatorcontrib><creatorcontrib>Goettems-Fiorin, Pauline Brendler</creatorcontrib><creatorcontrib>dos Santos, Jaíne Borges</creatorcontrib><creatorcontrib>Donato, Yohanna Hannnah</creatorcontrib><creatorcontrib>Wildner, Guilherme</creatorcontrib><creatorcontrib>de Bittencourt Júnior, Paulo Ivo Homem</creatorcontrib><creatorcontrib>Frizzo, Matias Nunes</creatorcontrib><creatorcontrib>Heck, Thiago Gomes</creatorcontrib><creatorcontrib>Ludwig, Mirna Stela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - 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Previous studies from our laboratory suggest an involvement of depressed heat shock response (HSR) in this scenario because estrogen potently stimulates HSR. As heat treatment induces the expression of the anti-inflammatory heat shock proteins of the 70-kDa family (HSP70) and its accompanying HSR, we aimed to investigate whether chronic heat treatment promotes beneficial effects on biometric, lipid profile, oxidative stress, and HSR in ovariectomized rats. Wistar adult female rats (n = 32) were divided into four groups: control (C, n = 7), ovariectomized (OVX, n = 9), heat-treated (HT, n = 9), and heat-treated ovariectomized rats (OVX+HT, n = 7). HTand OVX+HT rats were anesthetized and submitted to heat treatment (once a week for 12 weeks) in a water bath (41 °C) to increase rats’ rectal temperature up to 41 °C for 15 min, while C and OVX animals were submitted to a 36 °C water bath. HT attenuated the weight gain induced by OVX and increased HDL cholesterol and triglyceride serum levels. Also, OVX rats showed increased total cholesterol and LDL cholesterol levels that were not influenced by HT. Interestingly, it was found that an overall trend for HT to decrease tissue catalase and superoxide dismutase antioxidant activities was paralleled by a decrease in malondialdehyde levels (indicative of lower lipoperoxidation), especially in the skeletal muscle. Surprisingly, OVX was not able to depress intracellular HSP70 expression in the skeletal muscle, as expected, and this remained unchanged with HT. However, chronic HT did enhance intracellular HSP70 contents in white adipose tissue of OVX animals. As both glucose and insulin tolerance tests were not affected by OVX, which was not modified by HT, we suppose that estrogen absence alone is not sufficient to determine a state of insulin resistance associated with low intramuscular HSP70 content.</abstract><cop>Dordrecht</cop><pub>Springer Science + Business Media</pub><pmid>32215846</pmid><doi>10.1007/s12192-020-01087-z</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-0300-1511</orcidid><orcidid>https://orcid.org/0000-0002-1242-5423</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cell stress & chaperones, 2020-05, Vol.25 (3), p.467-479 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Adipose tissue Adipose Tissue, White - metabolism Animal tissues Animals Antioxidants Biochemistry Biomedical and Life Sciences Biomedicine Body weight gain Cancer Research Catalase Cell Biology Cholesterol Dyslipidemia Estrogens Female Glucose tolerance Glucose Tolerance Test Heat shock proteins Heat treatment Heat treatments Heat-Shock Response High density lipoprotein Hot Temperature HSP70 Heat-Shock Proteins - blood HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Immunology Inflammation Insulin Insulin resistance Intracellular Lipid Metabolism Lipids Lipids - blood Low density lipoprotein Malondialdehyde Muscles Muscles - metabolism Musculoskeletal system Neurosciences ORIGINAL PAPER Ovariectomy Oxidative Stress Rats, Wistar Rodents Serum levels Skeletal muscle Superoxide dismutase Triglycerides Water baths |
| title | Chronic heat treatment positively impacts metabolic profile of ovariectomized rats: association with heat shock response pathways |
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