Distinct genetic changes reveal evolutionary history and heterogeneous molecular grade of DLBCL with MYC/BCL2 double-hit

Using a Burkitt lymphoma-like gene expression signature, we recently defined a high-risk molecular high-grade (MHG) group mainly within germinal centre B-cell like diffuse large B-cell lymphomas (GCB-DLBCL), which was enriched for MYC / BCL2 double-hit ( MYC / BCL2 -DH). The genetic basis underlying...

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Veröffentlicht in:	Leukemia 2020-05, Vol.34 (5), p.1329-1341
Hauptverfasser:	Cucco, Francesco, Barrans, Sharon, Sha, Chulin, Clipson, Alexandra, Crouch, Simon, Dobson, Rachel, Chen, Zi, Thompson, Joe Sneath, Care, Matthew A., Cummin, Thomas, Caddy, Josh, Liu, Hongxiang, Robinson, Anne, Schuh, Anna, Fitzgibbon, Jude, Painter, Daniel, Smith, Alexandra, Roman, Eve, Tooze, Reuben, Burton, Catherine, Davies, Andrew J., Westhead, David R., Johnson, Peter W. M., Du, Ming-Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	14/32 45/23 631/208/2489 631/208/68 Amino acids B-cell lymphoma Biomarkers, Tumor - genetics Burkitt's lymphoma Cancer Cancer Research Clonal Evolution Critical Care Medicine Female Gene expression Gene Expression Profiling Gene Expression Regulation, Leukemic Gene Rearrangement Gene sequencing Genetic aspects Genetic transformation Hematology Humans Immunoglobulins Intensive Internal Medicine Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - pathology Lymphomas Male Medicine Medicine & Public Health Middle Aged Mutation Mutation hot spots Myc protein Oncology Phenotype Phosphorylation Prognosis Proteins Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-myc - genetics Survival Rate Translocation Translocation, Genetic Vincristine
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