Liver failure due to relapsed myeloma and hepatic iron overload
Multiple myeloma is a hematologic malignancy that classically manifests with hypercalcaemia, renal insufficiency, anaemia and lytic bone lesions. Liver dysfunction in multiple myeloma is a lesser known complication that occurs through biliary obstruction, liver infiltration by plasma cells, amyloid/...
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| Veröffentlicht in: | Ecancermedicalscience 2020-04, Vol.14, p.1028 |
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| creator | Chaulagain, Chakra P Gonzalez, Adalberto Goldszer, Isaac Caraballo, Luis Hoffman, James E Elson, Leah Diacovo, Maria-Julia |
| description | Multiple myeloma is a hematologic malignancy that classically manifests with hypercalcaemia, renal insufficiency, anaemia and lytic bone lesions. Liver dysfunction in multiple myeloma is a lesser known complication that occurs through biliary obstruction, liver infiltration by plasma cells, amyloid/light chain deposition or due to liver injury from medications. Although transfusion-related hepatic iron overload-leading to significant liver disease-is a recognised complication in certain hematologic malignancies, little is known about transfusional iron overload in patients with multiple myeloma. We present a case of a 49-year-old female with relapsed/refractory multiple myeloma who presented with rapid onset liver failure, due to both iron deposition and malignant plasma cell infiltration of the liver as a terminal event. A review of the literature on hepatic complications in multiple myeloma patients is presented. |
| doi_str_mv | 10.3332/ECANCER.2020.1028 |
| format | Article |
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Liver dysfunction in multiple myeloma is a lesser known complication that occurs through biliary obstruction, liver infiltration by plasma cells, amyloid/light chain deposition or due to liver injury from medications. Although transfusion-related hepatic iron overload-leading to significant liver disease-is a recognised complication in certain hematologic malignancies, little is known about transfusional iron overload in patients with multiple myeloma. We present a case of a 49-year-old female with relapsed/refractory multiple myeloma who presented with rapid onset liver failure, due to both iron deposition and malignant plasma cell infiltration of the liver as a terminal event. 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| subjects | Anemia Biopsy Blood Case Report Immunotherapy Iron Laboratories Liver diseases Multiple myeloma Patients Phosphatase Plasma Ultrasonic imaging |
| title | Liver failure due to relapsed myeloma and hepatic iron overload |
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