Documentation of hypoglycemia assessment among adults with diabetes during clinical encounters in primary care and endocrinology practices
Purpose To examine the proportion of diabetes-focused clinical encounters in primary care and endocrinology practices where the evaluation for hypoglycemia is documented; and when it is, identify clinicians’ stated actions in response to patient-reported events. Methods A total of 470 diabetes-focus...
Gespeichert in:
Veröffentlicht in: | Endocrine 2020-03, Vol.67 (3), p.552-560 |
---|---|
Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 560 |
---|---|
container_issue | 3 |
container_start_page | 552 |
container_title | Endocrine |
container_volume | 67 |
creator | Rodriguez-Gutierrez, Rene Salcido-Montenegro, Alejandro Singh-Ospina, Naykky M. Maraka, Spyridoula Iñiguez-Ariza, Nicole Spencer-Bonilla, Gabriela Tamhane, Shrikant U. Lipska, Kasia J. Montori, Victor M. McCoy, Rozalina G. |
description | Purpose
To examine the proportion of diabetes-focused clinical encounters in primary care and endocrinology practices where the evaluation for hypoglycemia is documented; and when it is, identify clinicians’ stated actions in response to patient-reported events.
Methods
A total of 470 diabetes-focused encounters among 283 patients nonpregnant adults (≥18 years) with type 1 or type 2 diabetes mellitus in this retrospective cohort study. Participants were randomly identified in blocks of treatment strategy and care location (95 and 52 primary care encounters among hypoglycemia-prone medications (i.e. insulin, sulfonylurea) and others patients, respectively; 94 and 42 endocrinology encounters among hypo-treated and others, respectively). Documentation of hypoglycemia and subsequent management plan in the electronic health record were evaluated.
Results
Overall, 132 (46.6%) patients had documentation of hypoglycemia assessment, significantly more prevalent among hypo-treated patients seen in endocrinology than in primary care (72.3% vs. 47.4%;
P
= 0.001). Hypoglycemia was identified by patient in 38.2% of encounters. Odds of hypoglycemia assessment documentation was highest among the hypo-treated (OR 13.6; 95% CI 5.5−33.74, vs. others) and patients seen in endocrine clinic (OR 4.48; 95% CI 2.3−8.6, vs. primary care). After documentation of hypoglycemia, treatment was modified in 30% primary care and 46% endocrine clinic encounters;
P
= 0.31. Few patients were referred to diabetes self-management education and support (DSMES).
Conclusions
Continued efforts to improve hypoglycemia evaluation, documentation, and management are needed, particularly in primary care. This includes not only screening at-risk patients for hypoglycemia, but also modifying their treatment regimens and/or leveraging DSMES. |
doi_str_mv | 10.1007/s12020-019-02147-w |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7192242</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2370562507</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-9500566b8bbc2c2f8ee4e51f90f6f30ad2b7bfb1a113a9ed602881fc7914f4363</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhS0Eoj_wAiyQJTZsAtd2EicbJFQoIFXqBiR2luNcz7hK7MF2GM0r8NR4OkNpWbCyrfPd43t0CHnB4A0DkG8T48ChAtZXwFktq-0jcsqapjyL_rjcRdNUAN33E3KW0g0A57yVT8mJYB1w0YhT8utDMMuMPuvsgqfB0vVuE1bTzuDsNNUpYUp7neo5-BXV4zLlRLcur-no9IAZEx2X6IpmJued0RNFb8LiM8ZEnaeb6GYdd9ToiFT7schjMGUiTGG1K7I22RlMz8gTq6eEz4_nOfl2-fHrxefq6vrTl4v3V5WpZZ2rvgFo2nbohsFww22HWGPDbA-2tQL0yAc52IFpxoTucWyBdx2zRvastrVoxTl5d_DdLMOMoynhop7UcU0VtFMPFe_WahV-Ksl6zmteDF4fDWL4sWDKanbJ4DRpj2FJigte6hAtEwV99Q96E5boS7xCyZKDNyALxQ-UiSGliPZuGQZqX7U6VK1K1eq2arUtQy_vx7gb-dNtAcQBSJt9PRj__v0f29-YabmD</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2370562507</pqid></control><display><type>article</type><title>Documentation of hypoglycemia assessment among adults with diabetes during clinical encounters in primary care and endocrinology practices</title><source>MEDLINE</source><source>Springer Online Journals</source><creator>Rodriguez-Gutierrez, Rene ; Salcido-Montenegro, Alejandro ; Singh-Ospina, Naykky M. ; Maraka, Spyridoula ; Iñiguez-Ariza, Nicole ; Spencer-Bonilla, Gabriela ; Tamhane, Shrikant U. ; Lipska, Kasia J. ; Montori, Victor M. ; McCoy, Rozalina G.</creator><creatorcontrib>Rodriguez-Gutierrez, Rene ; Salcido-Montenegro, Alejandro ; Singh-Ospina, Naykky M. ; Maraka, Spyridoula ; Iñiguez-Ariza, Nicole ; Spencer-Bonilla, Gabriela ; Tamhane, Shrikant U. ; Lipska, Kasia J. ; Montori, Victor M. ; McCoy, Rozalina G. ; Hypoglycemia as a Quality Measure in Diabetes Study Group ; on behalf of the Hypoglycemia as a Quality Measure in Diabetes Study Group</creatorcontrib><description>Purpose
To examine the proportion of diabetes-focused clinical encounters in primary care and endocrinology practices where the evaluation for hypoglycemia is documented; and when it is, identify clinicians’ stated actions in response to patient-reported events.
Methods
A total of 470 diabetes-focused encounters among 283 patients nonpregnant adults (≥18 years) with type 1 or type 2 diabetes mellitus in this retrospective cohort study. Participants were randomly identified in blocks of treatment strategy and care location (95 and 52 primary care encounters among hypoglycemia-prone medications (i.e. insulin, sulfonylurea) and others patients, respectively; 94 and 42 endocrinology encounters among hypo-treated and others, respectively). Documentation of hypoglycemia and subsequent management plan in the electronic health record were evaluated.
Results
Overall, 132 (46.6%) patients had documentation of hypoglycemia assessment, significantly more prevalent among hypo-treated patients seen in endocrinology than in primary care (72.3% vs. 47.4%;
P
= 0.001). Hypoglycemia was identified by patient in 38.2% of encounters. Odds of hypoglycemia assessment documentation was highest among the hypo-treated (OR 13.6; 95% CI 5.5−33.74, vs. others) and patients seen in endocrine clinic (OR 4.48; 95% CI 2.3−8.6, vs. primary care). After documentation of hypoglycemia, treatment was modified in 30% primary care and 46% endocrine clinic encounters;
P
= 0.31. Few patients were referred to diabetes self-management education and support (DSMES).
Conclusions
Continued efforts to improve hypoglycemia evaluation, documentation, and management are needed, particularly in primary care. This includes not only screening at-risk patients for hypoglycemia, but also modifying their treatment regimens and/or leveraging DSMES.</description><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-019-02147-w</identifier><identifier>PMID: 31802353</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Diabetes ; Diabetes mellitus (insulin dependent) ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - drug therapy ; Documentation ; Electronic medical records ; Endocrinology ; Humanities and Social Sciences ; Humans ; Hypoglycemia ; Hypoglycemia - diagnosis ; Hypoglycemia - epidemiology ; Hypoglycemic Agents - adverse effects ; Insulin ; Internal Medicine ; Medicine ; Medicine & Public Health ; multidisciplinary ; Original Article ; Patients ; Primary care ; Primary Health Care ; Retrospective Studies ; Science ; Sulfonylurea</subject><ispartof>Endocrine, 2020-03, Vol.67 (3), p.552-560</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>2019© Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-9500566b8bbc2c2f8ee4e51f90f6f30ad2b7bfb1a113a9ed602881fc7914f4363</citedby><cites>FETCH-LOGICAL-c474t-9500566b8bbc2c2f8ee4e51f90f6f30ad2b7bfb1a113a9ed602881fc7914f4363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12020-019-02147-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12020-019-02147-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31802353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodriguez-Gutierrez, Rene</creatorcontrib><creatorcontrib>Salcido-Montenegro, Alejandro</creatorcontrib><creatorcontrib>Singh-Ospina, Naykky M.</creatorcontrib><creatorcontrib>Maraka, Spyridoula</creatorcontrib><creatorcontrib>Iñiguez-Ariza, Nicole</creatorcontrib><creatorcontrib>Spencer-Bonilla, Gabriela</creatorcontrib><creatorcontrib>Tamhane, Shrikant U.</creatorcontrib><creatorcontrib>Lipska, Kasia J.</creatorcontrib><creatorcontrib>Montori, Victor M.</creatorcontrib><creatorcontrib>McCoy, Rozalina G.</creatorcontrib><creatorcontrib>Hypoglycemia as a Quality Measure in Diabetes Study Group</creatorcontrib><creatorcontrib>on behalf of the Hypoglycemia as a Quality Measure in Diabetes Study Group</creatorcontrib><title>Documentation of hypoglycemia assessment among adults with diabetes during clinical encounters in primary care and endocrinology practices</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description>Purpose
To examine the proportion of diabetes-focused clinical encounters in primary care and endocrinology practices where the evaluation for hypoglycemia is documented; and when it is, identify clinicians’ stated actions in response to patient-reported events.
Methods
A total of 470 diabetes-focused encounters among 283 patients nonpregnant adults (≥18 years) with type 1 or type 2 diabetes mellitus in this retrospective cohort study. Participants were randomly identified in blocks of treatment strategy and care location (95 and 52 primary care encounters among hypoglycemia-prone medications (i.e. insulin, sulfonylurea) and others patients, respectively; 94 and 42 endocrinology encounters among hypo-treated and others, respectively). Documentation of hypoglycemia and subsequent management plan in the electronic health record were evaluated.
Results
Overall, 132 (46.6%) patients had documentation of hypoglycemia assessment, significantly more prevalent among hypo-treated patients seen in endocrinology than in primary care (72.3% vs. 47.4%;
P
= 0.001). Hypoglycemia was identified by patient in 38.2% of encounters. Odds of hypoglycemia assessment documentation was highest among the hypo-treated (OR 13.6; 95% CI 5.5−33.74, vs. others) and patients seen in endocrine clinic (OR 4.48; 95% CI 2.3−8.6, vs. primary care). After documentation of hypoglycemia, treatment was modified in 30% primary care and 46% endocrine clinic encounters;
P
= 0.31. Few patients were referred to diabetes self-management education and support (DSMES).
Conclusions
Continued efforts to improve hypoglycemia evaluation, documentation, and management are needed, particularly in primary care. This includes not only screening at-risk patients for hypoglycemia, but also modifying their treatment regimens and/or leveraging DSMES.</description><subject>Adult</subject><subject>Diabetes</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Documentation</subject><subject>Electronic medical records</subject><subject>Endocrinology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hypoglycemia</subject><subject>Hypoglycemia - diagnosis</subject><subject>Hypoglycemia - epidemiology</subject><subject>Hypoglycemic Agents - adverse effects</subject><subject>Insulin</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>multidisciplinary</subject><subject>Original Article</subject><subject>Patients</subject><subject>Primary care</subject><subject>Primary Health Care</subject><subject>Retrospective Studies</subject><subject>Science</subject><subject>Sulfonylurea</subject><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0Eoj_wAiyQJTZsAtd2EicbJFQoIFXqBiR2luNcz7hK7MF2GM0r8NR4OkNpWbCyrfPd43t0CHnB4A0DkG8T48ChAtZXwFktq-0jcsqapjyL_rjcRdNUAN33E3KW0g0A57yVT8mJYB1w0YhT8utDMMuMPuvsgqfB0vVuE1bTzuDsNNUpYUp7neo5-BXV4zLlRLcur-no9IAZEx2X6IpmJued0RNFb8LiM8ZEnaeb6GYdd9ToiFT7schjMGUiTGG1K7I22RlMz8gTq6eEz4_nOfl2-fHrxefq6vrTl4v3V5WpZZ2rvgFo2nbohsFww22HWGPDbA-2tQL0yAc52IFpxoTucWyBdx2zRvastrVoxTl5d_DdLMOMoynhop7UcU0VtFMPFe_WahV-Ksl6zmteDF4fDWL4sWDKanbJ4DRpj2FJigte6hAtEwV99Q96E5boS7xCyZKDNyALxQ-UiSGliPZuGQZqX7U6VK1K1eq2arUtQy_vx7gb-dNtAcQBSJt9PRj__v0f29-YabmD</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Rodriguez-Gutierrez, Rene</creator><creator>Salcido-Montenegro, Alejandro</creator><creator>Singh-Ospina, Naykky M.</creator><creator>Maraka, Spyridoula</creator><creator>Iñiguez-Ariza, Nicole</creator><creator>Spencer-Bonilla, Gabriela</creator><creator>Tamhane, Shrikant U.</creator><creator>Lipska, Kasia J.</creator><creator>Montori, Victor M.</creator><creator>McCoy, Rozalina G.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200301</creationdate><title>Documentation of hypoglycemia assessment among adults with diabetes during clinical encounters in primary care and endocrinology practices</title><author>Rodriguez-Gutierrez, Rene ; Salcido-Montenegro, Alejandro ; Singh-Ospina, Naykky M. ; Maraka, Spyridoula ; Iñiguez-Ariza, Nicole ; Spencer-Bonilla, Gabriela ; Tamhane, Shrikant U. ; Lipska, Kasia J. ; Montori, Victor M. ; McCoy, Rozalina G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-9500566b8bbc2c2f8ee4e51f90f6f30ad2b7bfb1a113a9ed602881fc7914f4363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Diabetes</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Documentation</topic><topic>Electronic medical records</topic><topic>Endocrinology</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hypoglycemia</topic><topic>Hypoglycemia - diagnosis</topic><topic>Hypoglycemia - epidemiology</topic><topic>Hypoglycemic Agents - adverse effects</topic><topic>Insulin</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>multidisciplinary</topic><topic>Original Article</topic><topic>Patients</topic><topic>Primary care</topic><topic>Primary Health Care</topic><topic>Retrospective Studies</topic><topic>Science</topic><topic>Sulfonylurea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodriguez-Gutierrez, Rene</creatorcontrib><creatorcontrib>Salcido-Montenegro, Alejandro</creatorcontrib><creatorcontrib>Singh-Ospina, Naykky M.</creatorcontrib><creatorcontrib>Maraka, Spyridoula</creatorcontrib><creatorcontrib>Iñiguez-Ariza, Nicole</creatorcontrib><creatorcontrib>Spencer-Bonilla, Gabriela</creatorcontrib><creatorcontrib>Tamhane, Shrikant U.</creatorcontrib><creatorcontrib>Lipska, Kasia J.</creatorcontrib><creatorcontrib>Montori, Victor M.</creatorcontrib><creatorcontrib>McCoy, Rozalina G.</creatorcontrib><creatorcontrib>Hypoglycemia as a Quality Measure in Diabetes Study Group</creatorcontrib><creatorcontrib>on behalf of the Hypoglycemia as a Quality Measure in Diabetes Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodriguez-Gutierrez, Rene</au><au>Salcido-Montenegro, Alejandro</au><au>Singh-Ospina, Naykky M.</au><au>Maraka, Spyridoula</au><au>Iñiguez-Ariza, Nicole</au><au>Spencer-Bonilla, Gabriela</au><au>Tamhane, Shrikant U.</au><au>Lipska, Kasia J.</au><au>Montori, Victor M.</au><au>McCoy, Rozalina G.</au><aucorp>Hypoglycemia as a Quality Measure in Diabetes Study Group</aucorp><aucorp>on behalf of the Hypoglycemia as a Quality Measure in Diabetes Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Documentation of hypoglycemia assessment among adults with diabetes during clinical encounters in primary care and endocrinology practices</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>67</volume><issue>3</issue><spage>552</spage><epage>560</epage><pages>552-560</pages><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>Purpose
To examine the proportion of diabetes-focused clinical encounters in primary care and endocrinology practices where the evaluation for hypoglycemia is documented; and when it is, identify clinicians’ stated actions in response to patient-reported events.
Methods
A total of 470 diabetes-focused encounters among 283 patients nonpregnant adults (≥18 years) with type 1 or type 2 diabetes mellitus in this retrospective cohort study. Participants were randomly identified in blocks of treatment strategy and care location (95 and 52 primary care encounters among hypoglycemia-prone medications (i.e. insulin, sulfonylurea) and others patients, respectively; 94 and 42 endocrinology encounters among hypo-treated and others, respectively). Documentation of hypoglycemia and subsequent management plan in the electronic health record were evaluated.
Results
Overall, 132 (46.6%) patients had documentation of hypoglycemia assessment, significantly more prevalent among hypo-treated patients seen in endocrinology than in primary care (72.3% vs. 47.4%;
P
= 0.001). Hypoglycemia was identified by patient in 38.2% of encounters. Odds of hypoglycemia assessment documentation was highest among the hypo-treated (OR 13.6; 95% CI 5.5−33.74, vs. others) and patients seen in endocrine clinic (OR 4.48; 95% CI 2.3−8.6, vs. primary care). After documentation of hypoglycemia, treatment was modified in 30% primary care and 46% endocrine clinic encounters;
P
= 0.31. Few patients were referred to diabetes self-management education and support (DSMES).
Conclusions
Continued efforts to improve hypoglycemia evaluation, documentation, and management are needed, particularly in primary care. This includes not only screening at-risk patients for hypoglycemia, but also modifying their treatment regimens and/or leveraging DSMES.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31802353</pmid><doi>10.1007/s12020-019-02147-w</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1355-008X |
ispartof | Endocrine, 2020-03, Vol.67 (3), p.552-560 |
issn | 1355-008X 1559-0100 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7192242 |
source | MEDLINE; Springer Online Journals |
subjects | Adult Diabetes Diabetes mellitus (insulin dependent) Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Documentation Electronic medical records Endocrinology Humanities and Social Sciences Humans Hypoglycemia Hypoglycemia - diagnosis Hypoglycemia - epidemiology Hypoglycemic Agents - adverse effects Insulin Internal Medicine Medicine Medicine & Public Health multidisciplinary Original Article Patients Primary care Primary Health Care Retrospective Studies Science Sulfonylurea |
title | Documentation of hypoglycemia assessment among adults with diabetes during clinical encounters in primary care and endocrinology practices |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T16%3A09%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Documentation%20of%20hypoglycemia%20assessment%20among%20adults%20with%20diabetes%20during%20clinical%20encounters%20in%20primary%20care%20and%20endocrinology%20practices&rft.jtitle=Endocrine&rft.au=Rodriguez-Gutierrez,%20Rene&rft.aucorp=Hypoglycemia%20as%20a%20Quality%20Measure%20in%20Diabetes%20Study%20Group&rft.date=2020-03-01&rft.volume=67&rft.issue=3&rft.spage=552&rft.epage=560&rft.pages=552-560&rft.issn=1355-008X&rft.eissn=1559-0100&rft_id=info:doi/10.1007/s12020-019-02147-w&rft_dat=%3Cproquest_pubme%3E2370562507%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2370562507&rft_id=info:pmid/31802353&rfr_iscdi=true |