A Dynamic Immune Response Shapes COVID-19 Progression

The inflammatory response to SARS-coronavirus-2 (SARS-CoV-2) infection is thought to underpin COVID-19 pathogenesis. We conducted daily transcriptomic profiling of three COVID-19 cases and found that the early immune response in COVID-19 patients is highly dynamic. Patient throat swabs were tested d...

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Veröffentlicht in:	Cell host & microbe 2020-06, Vol.27 (6), p.879-882.e2
Hauptverfasser:	Ong, Eugenia Ziying, Chan, Yvonne Fu Zi, Leong, Wan Ying, Lee, Natalie Mei Ying, Kalimuddin, Shirin, Haja Mohideen, Salahudeen Mohamed, Chan, Kian Sing, Tan, Anthony Tanoto, Bertoletti, Antonio, Ooi, Eng Eong, Low, Jenny Guek Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological Variation, Individual Cluster Analysis Coronavirus Infections - blood Coronavirus Infections - genetics Coronavirus Infections - immunology Coronavirus Infections - pathology COVID-19 cytokine Cytokines - blood early immune response Gene Expression Regulation Humans IL1 Male Pandemics Pneumonia, Viral - blood Pneumonia, Viral - genetics Pneumonia, Viral - immunology Pneumonia, Viral - pathology SARS-CoV-2 T-cells Transcriptome transcriptomic profiling Up-Regulation
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