Adenosine inhibits the basolateral Cl - ClC-K2/b channel in collecting duct intercalated cells

Adenosine plays an important role in various aspects of kidney physiology, but the specific targets and mechanisms of actions are not completely understood. The collecting duct has the highest expression of adenosine receptors, particularly adenosine A receptors (A Rs). Interstitial adenosine levels...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2020-04, Vol.318 (4), p.F870-F877
Hauptverfasser:	Zaika, Oleg, Tomilin, Viktor N, Pochynyuk, Oleh
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine - pharmacology Adenosine A1 Receptor Agonists - pharmacology Adenosine A1 receptors Animals Anion Transport Proteins - antagonists & inhibitors Anion Transport Proteins - metabolism Calcium Signaling - drug effects Cells, Cultured Channel gating Channel opening Chloride Channels - antagonists & inhibitors Chloride Channels - metabolism Chlorides - metabolism Collecting duct Electrophysiology Kidney Tubules, Collecting - cytology Kidney Tubules, Collecting - drug effects Kidney Tubules, Collecting - metabolism Kidneys Male Membrane Potentials - drug effects Mice, Inbred C57BL Potassium channels (inwardly-rectifying) Potassium conductance Reabsorption Receptor, Adenosine A1 - drug effects Receptor, Adenosine A1 - metabolism Renal Reabsorption - drug effects Salt loading Sodium Sodium chloride
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