LDL induces cholesterol loading and inhibits endothelial proliferation and angiogenesis in Matrigels: correlation with impaired angiogenesis during wound healing

Hypercholesterolemia is a major risk factor for adverse cardiovascular outcomes, but its effect on angiogenesis and wound healing is not well understood. In this study, using a combination of mass spectrometry and laurdan two-photon imaging, we show that elevated levels of low-density lipoprotein (L...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2020-04, Vol.318 (4), p.C762-C776
Hauptverfasser:	Bogachkov, Yedida Y, Chen, Lin, Le Master, Elizabeth, Fancher, Ibra S, Zhao, Yan, Aguilar, Victor, Oh, Myung-Jin, Wary, Kishore K, DiPietro, Luisa A, Levitan, Irena
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apolipoprotein E Biopsy Cardiovascular diseases Cell adhesion & migration Cell adhesion molecules Cell cycle Cell differentiation Cell membranes Cells, Cultured Cholesterol Cholesterol - metabolism Collagen Drug Combinations Endothelial cells Endothelial Cells - metabolism Esters Fibroblast growth factor 2 Growth factors Hypercholesterolemia Hypercholesterolemia - blood Hypercholesterolemia - metabolism Laminin Lipoproteins, LDL - metabolism Low density lipoprotein Mass spectroscopy Mice Neovascularization, Pathologic - metabolism Proteoglycans Risk factors S phase Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vascular endothelial growth factor receptors Wound healing Wound Healing - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!