Identifying a subtype of Alzheimer’s disease characterised by predominant right focal cortical atrophy
We aimed to identify an Alzheimer’s disease (AD) subtype with right predominant focal atrophy. We recruited 17 amyloid PET positive logopenic variant primary progressive aphasia (lvPPA) and 226 amyloid PET positive AD patients. To identify AD with right focal atrophy (Rt-AD), we selected cortical ar...
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| Veröffentlicht in: | Scientific reports 2020-04, Vol.10 (1), p.7256-7256, Article 7256 |
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| description | We aimed to identify an Alzheimer’s disease (AD) subtype with right predominant focal atrophy. We recruited 17 amyloid PET positive logopenic variant primary progressive aphasia (lvPPA) and 226 amyloid PET positive AD patients. To identify AD with right focal atrophy (Rt-AD), we selected cortical areas that showed more atrophy in lvPPA than in AD and calculated an asymmetry index (AI) for this area in each individual. Using a receiver operating characteristic curve, we found that the optimal AI cut-off to discriminate lvPPA from AD was −3.1 (mean AI – 1.00 standard deviation) (sensitivity 88.2, specificity 89.8). We identified 32 Rt-AD patients whose AI was above mean AI + 1.00 standard deviation, 38 Lt-AD patients whose AI was lower than mean AI − 1.00 standard deviation, and 173 Symmetric-AD patients whose AI was within mean AI ± 1.00 standard deviation. We characterized clinical and cognitive profiles of Rt-AD patients by comparing with those of Lt-AD and Symmetric-AD patients. Compared to Symmetric-AD patients, Rt-AD patients had asymmetric focal atrophy in the right temporoparietal area and showed poor performance on visuospatial function testing (
p
= 0.009). Our findings suggested that there is an AD variant characterized by right focal atrophy and visuospatial dysfunction. |
| doi_str_mv | 10.1038/s41598-020-64180-4 |
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p
= 0.009). Our findings suggested that there is an AD variant characterized by right focal atrophy and visuospatial dysfunction.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-64180-4</identifier><identifier>PMID: 32350336</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59/57 ; 631/378/1689/132/1283 ; 692/617/375/132/1283 ; Aged ; Alzheimer Disease - classification ; Alzheimer Disease - pathology ; Alzheimer's disease ; Amyloid ; Aphasia ; Atrophy ; Atrophy - pathology ; Cerebral Cortex - pathology ; Cognitive ability ; Female ; Health risk assessment ; Humanities and Social Sciences ; Humans ; Inhibitor drugs ; Male ; Middle Aged ; multidisciplinary ; Neurodegenerative diseases ; Neuropsychological Tests ; Science ; Science (multidisciplinary) ; Standard deviation ; Toxicity</subject><ispartof>Scientific reports, 2020-04, Vol.10 (1), p.7256-7256, Article 7256</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-2b6eff10a13f8733edc412c1f3e204fecff55df0820550791088a10408443e1f3</citedby><cites>FETCH-LOGICAL-c474t-2b6eff10a13f8733edc412c1f3e204fecff55df0820550791088a10408443e1f3</cites><orcidid>0000-0001-9563-1849 ; 0000-0003-3152-1274</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190862/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190862/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,41099,42168,51554,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32350336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Ko Woon</creatorcontrib><creatorcontrib>Park, Seongbeom</creatorcontrib><creatorcontrib>Jo, Hyunjin</creatorcontrib><creatorcontrib>Cho, Soo Hyun</creatorcontrib><creatorcontrib>Kim, Seung Joo</creatorcontrib><creatorcontrib>Kim, Yeshin</creatorcontrib><creatorcontrib>Jang, Hyemin</creatorcontrib><creatorcontrib>Na, Duk L.</creatorcontrib><creatorcontrib>Seo, Sang Won</creatorcontrib><creatorcontrib>Kim, Hee Jin</creatorcontrib><title>Identifying a subtype of Alzheimer’s disease characterised by predominant right focal cortical atrophy</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>We aimed to identify an Alzheimer’s disease (AD) subtype with right predominant focal atrophy. We recruited 17 amyloid PET positive logopenic variant primary progressive aphasia (lvPPA) and 226 amyloid PET positive AD patients. To identify AD with right focal atrophy (Rt-AD), we selected cortical areas that showed more atrophy in lvPPA than in AD and calculated an asymmetry index (AI) for this area in each individual. Using a receiver operating characteristic curve, we found that the optimal AI cut-off to discriminate lvPPA from AD was −3.1 (mean AI – 1.00 standard deviation) (sensitivity 88.2, specificity 89.8). We identified 32 Rt-AD patients whose AI was above mean AI + 1.00 standard deviation, 38 Lt-AD patients whose AI was lower than mean AI − 1.00 standard deviation, and 173 Symmetric-AD patients whose AI was within mean AI ± 1.00 standard deviation. We characterized clinical and cognitive profiles of Rt-AD patients by comparing with those of Lt-AD and Symmetric-AD patients. Compared to Symmetric-AD patients, Rt-AD patients had asymmetric focal atrophy in the right temporoparietal area and showed poor performance on visuospatial function testing (
p
= 0.009). Our findings suggested that there is an AD variant characterized by right focal atrophy and visuospatial dysfunction.</description><subject>59/57</subject><subject>631/378/1689/132/1283</subject><subject>692/617/375/132/1283</subject><subject>Aged</subject><subject>Alzheimer Disease - classification</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Amyloid</subject><subject>Aphasia</subject><subject>Atrophy</subject><subject>Atrophy - pathology</subject><subject>Cerebral Cortex - pathology</subject><subject>Cognitive ability</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Inhibitor drugs</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Neurodegenerative diseases</subject><subject>Neuropsychological Tests</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Standard deviation</subject><subject>Toxicity</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1O3TAQha2KqiDKC3SBLHXDJq1_c50NEkK0RULqBtaWrzO-MUriYDuVworX6Ov1SWq4lAILvPFY880ZHx2EPlHyhRKuviZBZaMqwkhVC6pIJd6hPUaErBhnbOdZvYsOUrom5UjWCNp8QLuccUk4r_dQd97CmL1b_LjBBqd5nZcJcHD4pL_twA8Q_9z9Trj1CUwCbDsTjc0Qy7vF6wVPEdow-NGMGUe_6TJ2wZoe2xCzvy9MjmHqlo_ovTN9goPHex9dfTu7PP1RXfz8fn56clFZsRK5YusanKPEUO7UinNoraDMUsehGHJgnZOydUQxIiVZNZQoZSgRRAnBoWD76HirO83roUwXd9H0eop-MHHRwXj9sjP6Tm_CL72iDVE1KwJHjwIx3MyQsh58stD3ZoQwJ814UyspOK0L-vkVeh3mOBZ7DxRTjVC8UGxL2RhSiuCePkOJvs9Sb7PUJUv9kKUWZejwuY2nkX_JFYBvgVRa4wbi_91vyP4FGL-sPw</recordid><startdate>20200429</startdate><enddate>20200429</enddate><creator>Kim, Ko Woon</creator><creator>Park, Seongbeom</creator><creator>Jo, Hyunjin</creator><creator>Cho, Soo Hyun</creator><creator>Kim, Seung Joo</creator><creator>Kim, Yeshin</creator><creator>Jang, Hyemin</creator><creator>Na, Duk L.</creator><creator>Seo, Sang Won</creator><creator>Kim, Hee Jin</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9563-1849</orcidid><orcidid>https://orcid.org/0000-0003-3152-1274</orcidid></search><sort><creationdate>20200429</creationdate><title>Identifying a subtype of Alzheimer’s disease characterised by predominant right focal cortical atrophy</title><author>Kim, Ko Woon ; Park, Seongbeom ; Jo, Hyunjin ; Cho, Soo Hyun ; Kim, Seung Joo ; Kim, Yeshin ; Jang, Hyemin ; Na, Duk L. ; Seo, Sang Won ; Kim, Hee Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-2b6eff10a13f8733edc412c1f3e204fecff55df0820550791088a10408443e1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>59/57</topic><topic>631/378/1689/132/1283</topic><topic>692/617/375/132/1283</topic><topic>Aged</topic><topic>Alzheimer Disease - classification</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Amyloid</topic><topic>Aphasia</topic><topic>Atrophy</topic><topic>Atrophy - pathology</topic><topic>Cerebral Cortex - pathology</topic><topic>Cognitive ability</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Inhibitor drugs</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Neurodegenerative diseases</topic><topic>Neuropsychological Tests</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Standard deviation</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Ko Woon</creatorcontrib><creatorcontrib>Park, Seongbeom</creatorcontrib><creatorcontrib>Jo, Hyunjin</creatorcontrib><creatorcontrib>Cho, Soo Hyun</creatorcontrib><creatorcontrib>Kim, Seung Joo</creatorcontrib><creatorcontrib>Kim, Yeshin</creatorcontrib><creatorcontrib>Jang, Hyemin</creatorcontrib><creatorcontrib>Na, Duk L.</creatorcontrib><creatorcontrib>Seo, Sang Won</creatorcontrib><creatorcontrib>Kim, Hee Jin</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Ko Woon</au><au>Park, Seongbeom</au><au>Jo, Hyunjin</au><au>Cho, Soo Hyun</au><au>Kim, Seung Joo</au><au>Kim, Yeshin</au><au>Jang, Hyemin</au><au>Na, Duk L.</au><au>Seo, Sang Won</au><au>Kim, Hee Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identifying a subtype of Alzheimer’s disease characterised by predominant right focal cortical atrophy</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-04-29</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>7256</spage><epage>7256</epage><pages>7256-7256</pages><artnum>7256</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>We aimed to identify an Alzheimer’s disease (AD) subtype with right predominant focal atrophy. We recruited 17 amyloid PET positive logopenic variant primary progressive aphasia (lvPPA) and 226 amyloid PET positive AD patients. To identify AD with right focal atrophy (Rt-AD), we selected cortical areas that showed more atrophy in lvPPA than in AD and calculated an asymmetry index (AI) for this area in each individual. Using a receiver operating characteristic curve, we found that the optimal AI cut-off to discriminate lvPPA from AD was −3.1 (mean AI – 1.00 standard deviation) (sensitivity 88.2, specificity 89.8). We identified 32 Rt-AD patients whose AI was above mean AI + 1.00 standard deviation, 38 Lt-AD patients whose AI was lower than mean AI − 1.00 standard deviation, and 173 Symmetric-AD patients whose AI was within mean AI ± 1.00 standard deviation. We characterized clinical and cognitive profiles of Rt-AD patients by comparing with those of Lt-AD and Symmetric-AD patients. Compared to Symmetric-AD patients, Rt-AD patients had asymmetric focal atrophy in the right temporoparietal area and showed poor performance on visuospatial function testing (
p
= 0.009). Our findings suggested that there is an AD variant characterized by right focal atrophy and visuospatial dysfunction.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32350336</pmid><doi>10.1038/s41598-020-64180-4</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-9563-1849</orcidid><orcidid>https://orcid.org/0000-0003-3152-1274</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 59/57 631/378/1689/132/1283 692/617/375/132/1283 Aged Alzheimer Disease - classification Alzheimer Disease - pathology Alzheimer's disease Amyloid Aphasia Atrophy Atrophy - pathology Cerebral Cortex - pathology Cognitive ability Female Health risk assessment Humanities and Social Sciences Humans Inhibitor drugs Male Middle Aged multidisciplinary Neurodegenerative diseases Neuropsychological Tests Science Science (multidisciplinary) Standard deviation Toxicity |
| title | Identifying a subtype of Alzheimer’s disease characterised by predominant right focal cortical atrophy |
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