Brain distribution of geissoschizine methyl ether in rats using mass spectrometry imaging analysis

Geissoschizine methyl ether (GM) is one of the main active ingredients responsible for ameliorating the behavioral and psychological symptoms of dementia (BPSD) in Kampo medicine yokukansan. GM is mainly metabolized into hydroxylated forms (HM-1/2). However, the brain distributions of GM and HM has...

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Veröffentlicht in:	Scientific reports 2020-04, Vol.10 (1), p.7293, Article 7293
Hauptverfasser:	Matsumoto, Takashi, Ikarashi, Yasushi, Takiyama, Mikina, Watanabe, Junko, Setou, Mitsutoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45 631/92 Amygdala Animals Brain Brain - diagnostic imaging Brain - metabolism Cerebellum Cerebral cortex Dementia - diagnostic imaging Dementia - drug therapy Dementia - metabolism Dementia disorders Female Humanities and Social Sciences Indole Alkaloids - pharmacokinetics Indole Alkaloids - pharmacology Liquid chromatography Mass Spectrometry Mass spectroscopy Metabolites multidisciplinary Neostriatum Neuroimaging Parenchyma Plasma Rats Rats, Wistar Science Science (multidisciplinary) Scientific imaging Thalamus Time Factors Ventricle Ventricles (cerebral)
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