N-glycosylation of α1D-adrenergic receptor N-terminal domain is required for correct trafficking, function, and biogenesis

G protein-coupled receptor (GPCR) biogenesis, trafficking, and function are regulated by post-translational modifications, including N -glycosylation of asparagine residues. α 1D -adrenergic receptors (α 1D -ARs) – key regulators of central and autonomic nervous system function – contain two putativ...

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Veröffentlicht in:	Scientific reports 2020-04, Vol.10 (1), Article 7209
Hauptverfasser:	Janezic, Eric M., Lauer, Sophia My-Linh, Williams, Robert George, Chungyoun, Michael, Lee, Kyung-Soon, Navaluna, Edelmar, Lau, Ho-Tak, Ong, Shao-En, Hague, Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/612/1237 631/45/612/194 631/80/313 631/80/458 631/80/458/1524 Adrenergic receptors Asparagine Autonomic nervous system Biosynthesis Cell surface Confocal microscopy Cytosol Deficient mutant Fractionation G protein-coupled receptors Glycosylation Humanities and Social Sciences Localization multidisciplinary N-glycans Polysaccharides Post-translation Receptor mechanisms Science Science (multidisciplinary) Site-directed mutagenesis Sucrose
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