Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation

The paternal genome undergoes a massive exchange of histone with protamine for compaction into sperm during spermiogenesis. Upon fertilization, this process is potently reversed, which is essential for parental genome reprogramming and subsequent activation; however, it remains poorly understood how...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2020-03, Vol.180 (6), p.1212-1227.e14
Hauptverfasser:	Gou, Lan-Tao, Lim, Do-Hwan, Ma, Wubin, Aubol, Brandon E., Hao, Yajing, Wang, Xin, Zhao, Jun, Liang, Zhengyu, Shao, Changwei, Zhang, Xuan, Meng, Fan, Li, Hairi, Zhang, Xiaorong, Xu, Ruiming, Li, Dangsheng, Rosenfeld, Michael G., Mellon, Pamela L., Adams, Joseph A., Liu, Mo-Fang, Fu, Xiang-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Proteins - metabolism Cell Nucleus - metabolism chromatin Chromatin - metabolism Chromatin - physiology Chromatin Assembly and Disassembly - genetics Chromatin Assembly and Disassembly - physiology fertilization Fertilization - genetics genome genome reprogramming histone chaperones histones Histones - metabolism Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout oocytes Oocytes - metabolism Oocytes - physiology phase transition Phosphorylation pronucleus protamine Protamine Kinase - genetics Protamine Kinase - metabolism protamine-to-histone exchange Protamines - genetics Protamines - metabolism Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - physiology RNA Splicing - genetics RNA Splicing - physiology spermatozoa Spermatozoa - metabolism spermiogenesis SR protein-specific kinase Transcription Factors - metabolism Zygote - metabolism zygotic development
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!