The CDK inhibitor p57Kip2 enhances the activity of the transcriptional coactivator FHL2

The eukaryotic cell cycle is negatively regulated by cyclin-dependent kinase inhibitors (CKIs). p57 Kip2 is a member of the Cip/Kip family of CKIs and frequently inactivated by genomic mutations associated with human overgrowth disorders. There is increasing evidence for p57 to control cellular proc...

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Veröffentlicht in:	Scientific reports 2020-04, Vol.10 (1), p.7140-7140, Article 7140
Hauptverfasser:	Kullmann, Michael Keith, Podmirseg, Silvio Roland, Roilo, Martina, Hengst, Ludger
Format:	Artikel
Sprache:	eng
Schlagworte:	14/63 38/1 38/111 631/337/572 631/67/395 82/16 82/29 82/80 96/109 96/31 Apoptosis Cell cycle Cyclin-dependent kinase Cyclin-dependent kinase inhibitors Cyclin-dependent kinases FHL2 protein Gene regulation Gene silencing Genomics Histone deacetylase Humanities and Social Sciences Immunoprecipitation Inhibitors Kinases Kip protein LIM protein multidisciplinary Proteins Reporter gene Science Science (multidisciplinary) Sodium butyrate
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