CPNE1 predicts poor prognosis and promotes tumorigenesis and radioresistance via the AKT singling pathway in triple‐negative breast cancer

Elevated expression of Copine 1 (CPNE1) has been observed in multiple cancers; however, the underlying mechanisms by which it affects cancer cells are unclear. We aimed to study the effect of CPNE1 on the tumorigenesis and radioresistance of triple‐negative breast cancer (TNBC). Quantitative real‐ti...

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Veröffentlicht in:	Molecular carcinogenesis 2020-05, Vol.59 (5), p.533-544
Hauptverfasser:	Shao, Zhihong, Ma, Xiaolong, Zhang, Yufeng, Sun, Yuanyuan, Lv, Wenjuan, He, Kuigang, Xia, Rui, Wang, Peijun, Gao, Xiaolong
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT AKT protein Apoptosis Breast cancer Caspase Cell viability Cholecystokinin CPNE1 DNA damage Flow cytometry Immunofluorescence Immunohistochemistry Medical prognosis Metastases Poly(ADP-ribose) polymerase Polymerase chain reaction Radiation therapy Radioresistance Radiosensitivity triple‐negative breast cancer Tumorigenesis Xenografts
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