The role of innate lymphoid cells in response to microbes at mucosal surfaces
Innate lymphoid cells (ILCs) are a lymphocyte population that is mostly resident at mucosal surfaces. They help to induce an appropriate immune response to the microbiome at homeostasis. In healthy people, the mucosal immune system works symbiotically with organisms that make up the microbiota. ILCs...
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| Veröffentlicht in: | Mucosal immunology 2020-05, Vol.13 (3), p.399-412 |
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| creator | Seo, Goo-Young Giles, Daniel A. Kronenberg, Mitchell |
| description | Innate lymphoid cells (ILCs) are a lymphocyte population that is mostly resident at mucosal surfaces. They help to induce an appropriate immune response to the microbiome at homeostasis. In healthy people, the mucosal immune system works symbiotically with organisms that make up the microbiota. ILCs play a critical role in orchestrating this balance, as they can both influence and in turn be influenced by the microbiome. ILCs also are important regulators of the early response to infections by diverse types of pathogenic microbes at mucosal barriers. Their rapid responses initiate inflammatory programs, production of antimicrobial products and repair processes. This review will focus on the role of ILCs in response to the microbiota and to microbial infections of the lung and intestine. |
| doi_str_mv | 10.1038/s41385-020-0265-y |
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They help to induce an appropriate immune response to the microbiome at homeostasis. In healthy people, the mucosal immune system works symbiotically with organisms that make up the microbiota. ILCs play a critical role in orchestrating this balance, as they can both influence and in turn be influenced by the microbiome. ILCs also are important regulators of the early response to infections by diverse types of pathogenic microbes at mucosal barriers. Their rapid responses initiate inflammatory programs, production of antimicrobial products and repair processes. 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Giles, Daniel A. ; Kronenberg, Mitchell</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-3a408b3cbac28bca372bea71a637352715c4c5fe7b40443e46acf036a2c67c173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Allergology</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cytokines - metabolism</topic><topic>Gastroenterology</topic><topic>Homeostasis</topic><topic>Host-Parasite Interactions - immunology</topic><topic>Host-Pathogen Interactions - immunology</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immunity, Innate</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Intestine</topic><topic>Lymphocyte Subsets - immunology</topic><topic>Lymphocyte Subsets - metabolism</topic><topic>Lymphocytes</topic><topic>Lymphoid cells</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Microbiota - immunology</topic><topic>Microorganisms</topic><topic>Mucosal immunity</topic><topic>Mucous Membrane - immunology</topic><topic>Mucous Membrane - microbiology</topic><topic>Review Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seo, Goo-Young</creatorcontrib><creatorcontrib>Giles, Daniel A.</creatorcontrib><creatorcontrib>Kronenberg, Mitchell</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Mucosal immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seo, Goo-Young</au><au>Giles, Daniel A.</au><au>Kronenberg, Mitchell</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of innate lymphoid cells in response to microbes at mucosal surfaces</atitle><jtitle>Mucosal immunology</jtitle><stitle>Mucosal Immunol</stitle><addtitle>Mucosal Immunol</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>13</volume><issue>3</issue><spage>399</spage><epage>412</epage><pages>399-412</pages><issn>1933-0219</issn><eissn>1935-3456</eissn><abstract>Innate lymphoid cells (ILCs) are a lymphocyte population that is mostly resident at mucosal surfaces. 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| subjects | Allergology Animals Antibodies Biomarkers Biomedical and Life Sciences Biomedicine Cytokines - metabolism Gastroenterology Homeostasis Host-Parasite Interactions - immunology Host-Pathogen Interactions - immunology Humans Immune response Immunity, Innate Immunology Inflammation Intestine Lymphocyte Subsets - immunology Lymphocyte Subsets - metabolism Lymphocytes Lymphoid cells Microbiomes Microbiota Microbiota - immunology Microorganisms Mucosal immunity Mucous Membrane - immunology Mucous Membrane - microbiology Review Article |
| title | The role of innate lymphoid cells in response to microbes at mucosal surfaces |
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