The Effects of Furosemide on Oxygenation in Mechanically Ventilated Children with Bronchiolitis
Abstract Fluid balance management, including diuretic administration, may influence outcomes among mechanically ventilated children. We retrospectively compared oxygenation saturation index (OSI) before and after the initial furosemide bolus among 65 mechanically ventilated children. Furosemide was...
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| Veröffentlicht in: | Journal of pediatric intensive care 2020-06, Vol.9 (2), p.087-091 |
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| creator | Kulkarni, Mandar Slain, Katherine N. Rotta, Alexandre T. Shein, Steven L. |
| description | Abstract
Fluid balance management, including diuretic administration, may influence outcomes among mechanically ventilated children. We retrospectively compared oxygenation saturation index (OSI) before and after the initial furosemide bolus among 65 mechanically ventilated children. Furosemide was not associated with a significant change in median OSI (6.25 [interquartile range: 5.01–7.92] vs. 6.06 [4.73–7.54],
p
= 0.48), but was associated with expected changes in fluid balance and urine output. Secondary analysis suggested more favorable effects of furosemide in children with worse baseline OSI. The reported common use of furosemide by pediatric intensivists obligates further study to better establish its efficacy, or lack thereof, in mechanically ventilated children. |
| doi_str_mv | 10.1055/s-0039-3400467 |
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Fluid balance management, including diuretic administration, may influence outcomes among mechanically ventilated children. We retrospectively compared oxygenation saturation index (OSI) before and after the initial furosemide bolus among 65 mechanically ventilated children. Furosemide was not associated with a significant change in median OSI (6.25 [interquartile range: 5.01–7.92] vs. 6.06 [4.73–7.54],
p
= 0.48), but was associated with expected changes in fluid balance and urine output. Secondary analysis suggested more favorable effects of furosemide in children with worse baseline OSI. The reported common use of furosemide by pediatric intensivists obligates further study to better establish its efficacy, or lack thereof, in mechanically ventilated children.</description><identifier>ISSN: 2146-4618</identifier><identifier>EISSN: 2146-4626</identifier><identifier>DOI: 10.1055/s-0039-3400467</identifier><identifier>PMID: 32351761</identifier><language>eng</language><publisher>Stuttgart · New York: Georg Thieme Verlag KG</publisher><subject>Original ; Original Article</subject><ispartof>Journal of pediatric intensive care, 2020-06, Vol.9 (2), p.087-091</ispartof><rights>Thieme Medical Publishers.</rights><rights>Thieme Medical Publishers</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-41f62efe72343caed92f72020acad5a1f3802c5f781b30e73f7538c75c9eac5a3</citedby><orcidid>0000-0002-3325-3202 ; 0000-0001-7988-5654 ; 0000-0002-4406-2276 ; 0000-0003-3382-5159</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186015/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186015/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32351761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kulkarni, Mandar</creatorcontrib><creatorcontrib>Slain, Katherine N.</creatorcontrib><creatorcontrib>Rotta, Alexandre T.</creatorcontrib><creatorcontrib>Shein, Steven L.</creatorcontrib><title>The Effects of Furosemide on Oxygenation in Mechanically Ventilated Children with Bronchiolitis</title><title>Journal of pediatric intensive care</title><addtitle>J Pediatr Intensive Care</addtitle><description>Abstract
Fluid balance management, including diuretic administration, may influence outcomes among mechanically ventilated children. We retrospectively compared oxygenation saturation index (OSI) before and after the initial furosemide bolus among 65 mechanically ventilated children. Furosemide was not associated with a significant change in median OSI (6.25 [interquartile range: 5.01–7.92] vs. 6.06 [4.73–7.54],
p
= 0.48), but was associated with expected changes in fluid balance and urine output. Secondary analysis suggested more favorable effects of furosemide in children with worse baseline OSI. The reported common use of furosemide by pediatric intensivists obligates further study to better establish its efficacy, or lack thereof, in mechanically ventilated children.</description><subject>Original</subject><subject>Original Article</subject><issn>2146-4618</issn><issn>2146-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kU1vFDEMhiMEolXplSPKkcuUfEySmQsSrFpAatVL4RqlGaeTKpOUJFPYf0-qXVZwqC-25MevLb8IvaXkjBIhPpSOED52vCekl-oFOma0l10vmXx5qOlwhE5LuSctVE-oHF-jI864oErSY6RvZsDnzoGtBSeHL9acCix-Apwivv69vYNoqm-1j_gK7GyityaELf4BsfpgKkx4M_swZYj4l68z_pxTtLNPwVdf3qBXzoQCp_t8gr5fnN9svnaX11--bT5ddpaLoXY9dZKBA8V4z62BaWROMcKIsWYShjo-EGaFUwO95QQUd0rwwSphRzBWGH6CPu50H9bbBSbbjssm6IfsF5O3Ohmv_-9EP-u79KgVHSShogm83wvk9HOFUvXii4UQTIS0Fs34KAchBBsaerZDbftVyeAOayjRT8boop-M0Xtj2sC7f4874H9taEC3A-rsYQF9n9Yc27ueE_wDNpGYrw</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Kulkarni, Mandar</creator><creator>Slain, Katherine N.</creator><creator>Rotta, Alexandre T.</creator><creator>Shein, Steven L.</creator><general>Georg Thieme Verlag KG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3325-3202</orcidid><orcidid>https://orcid.org/0000-0001-7988-5654</orcidid><orcidid>https://orcid.org/0000-0002-4406-2276</orcidid><orcidid>https://orcid.org/0000-0003-3382-5159</orcidid></search><sort><creationdate>20200601</creationdate><title>The Effects of Furosemide on Oxygenation in Mechanically Ventilated Children with Bronchiolitis</title><author>Kulkarni, Mandar ; Slain, Katherine N. ; Rotta, Alexandre T. ; Shein, Steven L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-41f62efe72343caed92f72020acad5a1f3802c5f781b30e73f7538c75c9eac5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Original</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kulkarni, Mandar</creatorcontrib><creatorcontrib>Slain, Katherine N.</creatorcontrib><creatorcontrib>Rotta, Alexandre T.</creatorcontrib><creatorcontrib>Shein, Steven L.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of pediatric intensive care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kulkarni, Mandar</au><au>Slain, Katherine N.</au><au>Rotta, Alexandre T.</au><au>Shein, Steven L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Furosemide on Oxygenation in Mechanically Ventilated Children with Bronchiolitis</atitle><jtitle>Journal of pediatric intensive care</jtitle><addtitle>J Pediatr Intensive Care</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>9</volume><issue>2</issue><spage>087</spage><epage>091</epage><pages>087-091</pages><issn>2146-4618</issn><eissn>2146-4626</eissn><abstract>Abstract
Fluid balance management, including diuretic administration, may influence outcomes among mechanically ventilated children. We retrospectively compared oxygenation saturation index (OSI) before and after the initial furosemide bolus among 65 mechanically ventilated children. Furosemide was not associated with a significant change in median OSI (6.25 [interquartile range: 5.01–7.92] vs. 6.06 [4.73–7.54],
p
= 0.48), but was associated with expected changes in fluid balance and urine output. Secondary analysis suggested more favorable effects of furosemide in children with worse baseline OSI. The reported common use of furosemide by pediatric intensivists obligates further study to better establish its efficacy, or lack thereof, in mechanically ventilated children.</abstract><cop>Stuttgart · New York</cop><pub>Georg Thieme Verlag KG</pub><pmid>32351761</pmid><doi>10.1055/s-0039-3400467</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-3325-3202</orcidid><orcidid>https://orcid.org/0000-0001-7988-5654</orcidid><orcidid>https://orcid.org/0000-0002-4406-2276</orcidid><orcidid>https://orcid.org/0000-0003-3382-5159</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Original Original Article |
| title | The Effects of Furosemide on Oxygenation in Mechanically Ventilated Children with Bronchiolitis |
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