Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial

Middle East respiratory syndrome (MERS) coronavirus causes a highly fatal lower-respiratory tract infection. There are as yet no licensed MERS vaccines or therapeutics. This study (WRAIR-2274) assessed the safety, tolerability, and immunogenicity of the GLS-5300 MERS coronavirus DNA vaccine in healt...

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Veröffentlicht in:	The Lancet infectious diseases 2019-09, Vol.19 (9), p.1013-1022
Hauptverfasser:	Modjarrad, Kayvon, Roberts, Christine C, Mills, Kristin T, Castellano, Amy R, Paolino, Kristopher, Muthumani, Kar, Reuschel, Emma L, Robb, Merlin L, Racine, Trina, Oh, Myoung-don, Lamarre, Claude, Zaidi, Faraz I, Boyer, Jean, Kudchodkar, Sagar B, Jeong, Moonsup, Darden, Janice M, Park, Young K, Scott, Paul T, Remigio, Celine, Parikh, Ajay P, Wise, Megan C, Patel, Ami, Duperret, Elizabeth K, Kim, Kevin Y, Choi, Hyeree, White, Scott, Bagarazzi, Mark, May, Jeanine M, Kane, Deborah, Lee, Hyojin, Kobinger, Gary, Michael, Nelson L, Weiner, David B, Thomas, Stephen J, Maslow, Joel N
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adults Antibodies Birth control Clinical trials Coronaviridae Coronaviruses COVID-19 Creatine Creatine kinase Deoxyribonucleic acid DNA DNA vaccines Electrocardiography Electroporation Enzyme-linked immunosorbent assay Federal agencies Headache Hepatitis Immune response Immunogenicity Immunoglobulins Infections Infectious diseases Injection Laboratories Lymphocytes T Pain Respiratory diseases Respiratory tract Respiratory tract diseases Safety Seroconversion Vaccines
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