Genome-Wide Screens Identify Group A Streptococcus Surface Proteins Promoting Female Genital Tract Colonization and Virulence

Group A streptococcus (GAS) is a major pathogen that impacts health and economic affairs worldwide. Although the oropharynx is the primary site of infection, GAS can colonize the female genital tract and cause severe diseases, such as puerperal sepsis, neonatal infections, and necrotizing myometriti...

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Veröffentlicht in:	The American journal of pathology 2020-04, Vol.190 (4), p.862-873
Hauptverfasser:	Zhu, Luchang, Olsen, Randall J., Beres, Stephen B., Ojeda Saavedra, Matthew, Kubiak, Samantha L., Cantu, Concepcion C., Jenkins, Leslie, Yerramilli, Prasanti, Pruitt, Layne, Charbonneau, Amelia R.L., Waller, Andrew S., Musser, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - genetics Bacterial Proteins - metabolism Disease Models, Animal Female Gene Expression Regulation, Bacterial Macaca fascicularis Membrane Proteins - genetics Membrane Proteins - metabolism Streptococcal Infections - metabolism Streptococcal Infections - microbiology Streptococcus pyogenes - genetics Streptococcus pyogenes - metabolism Streptococcus pyogenes - pathogenicity Vaginal Diseases - microbiology Vaginal Diseases - pathology Virulence
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