p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis

The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has remained unclear. Here, we identify Pvt1b, a p53-dependent isoform of the long noncoding...

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Veröffentlicht in:	Molecular cell 2020-02, Vol.77 (4), p.761-774.e8
Hauptverfasser:	Olivero, Christiane E., Martínez-Terroba, Elena, Zimmer, Joshua, Liao, Clara, Tesfaye, Ephrath, Hooshdaran, Nima, Schofield, Jeremy A., Bendor, Jordan, Fang, Dorthy, Simon, Matthew D., Zamudio, Jesse R., Dimitrova, Nadya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogenesis - genetics Cell Line Cell Proliferation Cells, Cultured Chromatin - metabolism Enhancer Elements, Genetic Gene Expression Regulation Humans long noncoding RNA lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Mice Mice, Inbred C57BL mouse model of cancer MYC p53 Promoter Regions, Genetic Proto-Oncogene Proteins c-myc - antagonists & inhibitors Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Pvt1 RNA, Long Noncoding - antagonists & inhibitors RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Stress, Physiological - genetics tumor suppressor Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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