Determining the role for uric acid in non-alcoholic steatohepatitis development and the utility of urate metabolites in diagnosis: An opinion review
There has long been a recognised association between non-alcoholic fatty liver disease (NAFLD) and the composite aspects of the metabolic syndrome. Part of this association highlighted the supposed co-existence of elevated uric acid levels in those with NAFLD. There is interest in exploitation of th...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2020-04, Vol.26 (15), p.1683-1690 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Brennan, Paul Clare, Kathleen George, Jacob Dillon, John F |
| description | There has long been a recognised association between non-alcoholic fatty liver disease (NAFLD) and the composite aspects of the metabolic syndrome. Part of this association highlighted the supposed co-existence of elevated uric acid levels in those with NAFLD. There is interest in exploitation of this as a putative diagnostic and prognostic biomarker in NAFLD. Given the increased economic and health burden associated with the NAFLD epidemic, improved methods of population-based, minimally-invasive methods and biomarkers are clearly highly sought and necessary. In this opinion review we review the proposed role of uric acid in the pathogenesis of NAFLD and its potential utilisation in the diagnosis and monitoring of the disease process. |
| doi_str_mv | 10.3748/wjg.v26.i15.1683 |
| format | Article |
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| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2020-04, Vol.26 (15), p.1683-1690 |
| issn | 1007-9327 2219-2840 |
| language | eng |
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| source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Biomarkers - blood Biomarkers - metabolism Humans Hyperuricemia - blood Hyperuricemia - complications Hyperuricemia - diagnosis Liver - metabolism Liver - pathology Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - diagnosis Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - metabolism Opinion Review Uric Acid - blood Uric Acid - metabolism |
| title | Determining the role for uric acid in non-alcoholic steatohepatitis development and the utility of urate metabolites in diagnosis: An opinion review |
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