The T1D-associated lncRNA Lnc13 modulates human pancreatic β cell inflammation by allele-specific stabilization of STAT1 mRNA

The vast majority of type 1 diabetes (T1D) genetic association signals lie in noncoding regions of the human genome. Many have been predicted to affect the expression and secondary structure of long noncoding RNAs (lncRNAs), but the contribution of these lncRNAs to the pathogenesis of T1D remains to...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-04, Vol.117 (16), p.9022-9031
Hauptverfasser:	Gonzalez-Moro, Itziar, Olazagoitia-Garmendia, Ane, Colli, Maikel L., Cobo-Vuilleumier, Nadia, Postler, Thomas S., Marselli, Lorella, Marchetti, Piero, Ghosh, Sankar, Gauthier, Benoit R., Eizirik, Decio L., Castellanos-Rubio, Ainara, Santin, Izortze
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Beta cells Biological Sciences Cell activation Chemokines Cytoplasm Diabetes mellitus (insulin dependent) Diagnostic systems Gene disruption Gene expression Gene polymorphism Genomes Inflammation Molecular modelling mRNA stability Nucleotides Pancreas Pathogenesis Polyinosinic:polycytidylic acid Polymorphism Protein structure Secondary structure Single-nucleotide polymorphism Stat1 protein Translocation
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