Review Analysis on Thymectomy vs Conservative Medical Management in Myasthenia Gravis
Myasthenia gravis (MG) is an acquired, rare autoimmune disease that occurs due to autoantibodies blocking neuromuscular transmission. Its pathophysiology involves production of antibodies against the nicotinic acetylcholine receptors. Patients with negative anti-acetylcholine receptors (AChR) antibo...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2020-03, Vol.12 (3), p.e7425 |
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| creator | Rashid, Muhammad Humayoun Yasir, Hafiz Khawaja Muhammad Piracha, Muhammad Usman Salman, Umer Yousaf, Hamza |
| description | Myasthenia gravis (MG) is an acquired, rare autoimmune disease that occurs due to autoantibodies blocking neuromuscular transmission. Its pathophysiology involves production of antibodies against the nicotinic acetylcholine receptors. Patients with negative anti-acetylcholine receptors (AChR) antibodies results are recognized as seronegative myasthenia gravis. In this review we tried to compare surgical and medical management of MG with each other to find out which is more effective. Different clinical trials and retrospective cohorts comparing these two parameters statistically were searched and studied. Remission rates in both medical and surgical management were compared. We found out that rates of remission were better in post thymectomy patients than patients on various medical treatment options including corticosteroids, immunosuppressants, intravenous immunoglobulins and acetylcholinesterase inhibitors alone. Hence thymectomy is studied to be the superior treatment option than other conservative medical management options alone. |
| doi_str_mv | 10.7759/cureus.7425 |
| format | Article |
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Its pathophysiology involves production of antibodies against the nicotinic acetylcholine receptors. Patients with negative anti-acetylcholine receptors (AChR) antibodies results are recognized as seronegative myasthenia gravis. In this review we tried to compare surgical and medical management of MG with each other to find out which is more effective. Different clinical trials and retrospective cohorts comparing these two parameters statistically were searched and studied. Remission rates in both medical and surgical management were compared. We found out that rates of remission were better in post thymectomy patients than patients on various medical treatment options including corticosteroids, immunosuppressants, intravenous immunoglobulins and acetylcholinesterase inhibitors alone. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2020, Rashid et al. 2020 Rashid et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182154/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182154/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32337145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rashid, Muhammad Humayoun</creatorcontrib><creatorcontrib>Yasir, Hafiz Khawaja Muhammad</creatorcontrib><creatorcontrib>Piracha, Muhammad Usman</creatorcontrib><creatorcontrib>Salman, Umer</creatorcontrib><creatorcontrib>Yousaf, Hamza</creatorcontrib><title>Review Analysis on Thymectomy vs Conservative Medical Management in Myasthenia Gravis</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Myasthenia gravis (MG) is an acquired, rare autoimmune disease that occurs due to autoantibodies blocking neuromuscular transmission. 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| subjects | Antibodies Apheresis Autoimmune diseases Cardiac/Thoracic/Vascular Surgery Clinical outcomes Electromyography Immunoglobulins Immunotherapy Internal Medicine Intubation Medical treatment Mortality Neurology Paralysis Remission (Medicine) Surgery Surgical outcomes |
| title | Review Analysis on Thymectomy vs Conservative Medical Management in Myasthenia Gravis |
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