Flavin Binding Allosteric Aptamer with Noncovalent Labeling for miR Sensing

Modular allosteric aptamers with discrete recognition and signaling regions provide a facile method of carrying out label-free detection by forgoing complex target labeling requirements. Herein, we describe the design and function of an aptamer scaffold capable of forming a hairpin loop in the prese...

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Veröffentlicht in:	Bioconjugate chemistry 2019-11, Vol.30 (11), p.2822-2827
Hauptverfasser:	Gee, A, Grennell, J. A, Sitaula, S, Jayawickramarajah, J, Ali, M. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric properties Aptamers Flavin-adenine dinucleotide Hybridization Labeling miRNA Nucleotides Recognition Ribonucleic acid RNA Signaling Target detection
Online-Zugang:	Volltext
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