SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice

Abstract Establishment of the primordial follicle (PF) pool is pivotal for the female reproductive lifespan; however, the mechanism of primordial folliculogenesis is poorly understood. Here, the transcription factor SP1 was shown to be essential for PF formation in mice. Our results showed that SP1...

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Veröffentlicht in:	Journal of molecular cell biology 2020-04, Vol.12 (3), p.230-244
Hauptverfasser:	Cai, Han, Liu, Bingying, Wang, Huarong, Sun, Guanghong, Feng, Lizhao, Chen, Ziqi, Zhou, Jiaqi, Zhang, Jiawei, Zhang, Tuo, He, Meina, Yang, Tingting, Guo, Qirui, Teng, Zhen, Xin, Qiliang, Zhou, Bo, Zhang, Hua, Xia, Guoliang, Wang, Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Biomarkers Disease Susceptibility Female Fluorescent Antibody Technique Forkhead Box Protein L2 - metabolism Gene Expression Regulation, Developmental Gene Knockdown Techniques Granulosa Cells - cytology Granulosa Cells - metabolism Hepatocyte Nuclear Factor 1-alpha - metabolism Mice Oocytes - metabolism Ovarian Follicle - growth & development Ovarian Follicle - metabolism Primary Ovarian Insufficiency - etiology Primary Ovarian Insufficiency - metabolism Promoter Regions, Genetic Receptor, Notch2 - genetics Receptor, Notch2 - metabolism Sexual Maturation - genetics Signal Transduction
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