Identification of early pericyte loss and vascular amyloidosis in Alzheimer’s disease retina

Pericyte loss and deficient vascular platelet-derived growth factor receptor-β (PDGFRβ) signaling are prominent features of the blood–brain barrier breakdown described in Alzheimer’s disease (AD) that can predict cognitive decline yet have never been studied in the retina. Recent reports using nonin...

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Veröffentlicht in:	Acta neuropathologica 2020-05, Vol.139 (5), p.813-836
Hauptverfasser:	Shi, Haoshen, Koronyo, Yosef, Rentsendorj, Altan, Regis, Giovanna C., Sheyn, Julia, Fuchs, Dieu-Trang, Kramerov, Andrei A., Ljubimov, Alexander V., Dumitrascu, Oana M., Rodriguez, Anthony R., Barron, Ernesto, Hinton, David R., Black, Keith L., Miller, Carol A., Mirzaei, Nazanin, Koronyo-Hamaoui, Maya
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Aged Aged, 80 and over Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-protein Amyloid beta-Protein Precursor - metabolism Amyloidosis Amyloidosis - complications Amyloidosis - pathology Angiography Apoptosis Autopsy Blood-brain barrier Blood-Brain Barrier - pathology Brain - pathology Cerebral amyloid angiopathy Cerebral Amyloid Angiopathy - pathology Cognition - physiology Cognitive ability Diagnostic imaging Female Humans Male Medical colleges Medical research Medicine Medicine & Public Health Medicine, Experimental Microvasculature Molecular modelling Neurodegenerative diseases Neuroimaging Neurosciences Original Paper Pathology Pericytes Pericytes - pathology Platelet-derived growth factor Retina Retina - pathology Risk factors
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