Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma

Recent evidence suggests that hepatocellular carcinoma (HCC) is organized by a subset of cells with stem cell features (cancer stem cells; CSCs). CSCs are considered a pivotal target for the eradication of cancer, and liver CSCs have been identified by the use of various stem cell markers. However,...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2013-04, Vol.57 (4), p.1484-1497
Hauptverfasser:	Yamashita, Taro, Honda, Masao, Nakamoto, Yasunari, Baba, Masayo, Nio, Kouki, Hara, Yasumasa, Zeng, Sha Sha, Hayashi, Takehiro, Kondo, Mitsumasa, Takatori, Hajime, Yamashita, Tatsuya, Mizukoshi, Eishiro, Ikeda, Hiroko, Zen, Yoh, Takamura, Hiroyuki, Wang, Xin Wei, Kaneko, Shuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Antigens, Neoplasm - metabolism Antineoplastic Agents - pharmacology Benzamides - pharmacology Biomarkers, Tumor - metabolism Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Adhesion Molecules - metabolism Cell Line, Tumor Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Epithelial Cell Adhesion Molecule Epithelial Cells - metabolism Epithelial Cells - pathology Female Hepatology Humans Imatinib Mesylate In Vitro Techniques Liver cancer Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Mice Mice, SCID Middle Aged Motility Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Piperazines - pharmacology Pyrimidines - pharmacology Stem cells Thy-1 Antigens - metabolism Transplantation, Heterologous
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