Oncogenic Mutations in Armadillo Repeats 5 and 6 of β-Catenin Reduce Binding to APC, Increasing Signaling and Transcription of Target Genes

The β-catenin signaling pathway is one of the most commonly deregulated pathways in cancer cells. Amino acid substitutions within armadillo repeats 5 and 6 (K335, W383, and N387) of β-catenin are found in several tumor types, including liver tumors. We investigated the mechanisms by which these subs...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2020-03, Vol.158 (4), p.1029-1043.e10
Hauptverfasser:	Liu, Pengyu, Liang, Binyong, Liu, Menggang, Lebbink, Joyce H.G., Li, Shan, Qian, Manning, Lavrijsen, Marla, Peppelenbosch, Maikel P., Chen, Xin, Smits, Ron
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - genetics Carcinogenesis - genetics Gene Regulation Genes, APC - physiology HCT116 Cells HEK293 Cells Hepatocarcinogenesis Hepatocellular Carcinoma Humans Liver - metabolism Liver Neoplasms - genetics Mice Mouse Model Mutation Plasmids - pharmacology Proto-Oncogene Proteins c-met Transcription, Genetic Wnt Signaling Pathway - genetics
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