Insecticidal Activity of Doxycycline against the Common Bedbug
There is an ongoing need for safe and effective anti-bedbug compounds. Here, we tested the toxicity of three antimicrobial agents against bedbugs when administered orally. We reveal that doxycycline has direct insecticidal activity at 250 μg/ml (0.025%) that is particularly strong against immature b...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2020-04, Vol.64 (5) |
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| container_title | Antimicrobial agents and chemotherapy |
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| creator | Pietri, Jose E Liang, Dangsheng |
| description | There is an ongoing need for safe and effective anti-bedbug compounds. Here, we tested the toxicity of three antimicrobial agents against bedbugs when administered orally. We reveal that doxycycline has direct insecticidal activity at 250 μg/ml (0.025%) that is particularly strong against immature bedbugs and appears to be independent of antimicrobial activity. Future studies to determine the mechanisms behind this property could be useful for the development of orally active insecticides or anti-bedbug therapeutics. |
| doi_str_mv | 10.1128/AAC.00005-20 |
| format | Article |
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Here, we tested the toxicity of three antimicrobial agents against bedbugs when administered orally. We reveal that doxycycline has direct insecticidal activity at 250 μg/ml (0.025%) that is particularly strong against immature bedbugs and appears to be independent of antimicrobial activity. Future studies to determine the mechanisms behind this property could be useful for the development of orally active insecticides or anti-bedbug therapeutics.</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.00005-20</identifier><identifier>PMID: 32122896</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; Bedbugs - drug effects ; Bedbugs - microbiology ; Doxycycline - pharmacology ; Experimental Therapeutics ; Insecticides - pharmacology ; Penicillins - pharmacology ; Rifampin - pharmacology ; Symbiosis - drug effects ; Wolbachia - drug effects ; Wolbachia - metabolism</subject><ispartof>Antimicrobial agents and chemotherapy, 2020-04, Vol.64 (5)</ispartof><rights>Copyright © 2020 American Society for Microbiology.</rights><rights>Copyright © 2020 American Society for Microbiology. 2020 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a418t-d4fd6ae1f580328dc779b394703d77a05ef8baa3d28343e4cdeb3aab7f7f8e143</citedby><cites>FETCH-LOGICAL-a418t-d4fd6ae1f580328dc779b394703d77a05ef8baa3d28343e4cdeb3aab7f7f8e143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179621/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179621/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32122896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pietri, Jose E</creatorcontrib><creatorcontrib>Liang, Dangsheng</creatorcontrib><title>Insecticidal Activity of Doxycycline against the Common Bedbug</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>There is an ongoing need for safe and effective anti-bedbug compounds. Here, we tested the toxicity of three antimicrobial agents against bedbugs when administered orally. We reveal that doxycycline has direct insecticidal activity at 250 μg/ml (0.025%) that is particularly strong against immature bedbugs and appears to be independent of antimicrobial activity. Future studies to determine the mechanisms behind this property could be useful for the development of orally active insecticides or anti-bedbug therapeutics.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bedbugs - drug effects</subject><subject>Bedbugs - microbiology</subject><subject>Doxycycline - pharmacology</subject><subject>Experimental Therapeutics</subject><subject>Insecticides - pharmacology</subject><subject>Penicillins - pharmacology</subject><subject>Rifampin - pharmacology</subject><subject>Symbiosis - drug effects</subject><subject>Wolbachia - drug effects</subject><subject>Wolbachia - metabolism</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtLw0AQxhdRbK3ePEuugqn7SnZzKcT4KhS86HnZ7KPdkkfJpsX8965Wix6cywx833zM_AC4RHCKEOa3eV5MYagkxvAIjBHMeJwmWXoMxhCmaUw5pCNw5v06mIIAT8GIYIQxz9IxmM0bb1TvlNOyivIw7Vw_RK2N7tv3QQ2qco2J5FK6xvdRvzJR0dZ120R3Rpfb5Tk4sbLy5uK7T8Db48Nr8RwvXp7mRb6IJUW8jzW1OpUG2YRDgrlWjGUlySiDRDMmYWIsL6UkGnNCiaFKm5JIWTLLLDeIkgmY7XM327I2Wpmm72QlNp2rZTeIVjrxV2ncSizbnWCIZSlGIeBmH6C61vvO2MMuguKTowgcxRdHgWGwX-_t0tdYrNtt14T3_vNe_b7tEPwDmXwAhCd7rQ</recordid><startdate>20200421</startdate><enddate>20200421</enddate><creator>Pietri, Jose E</creator><creator>Liang, Dangsheng</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20200421</creationdate><title>Insecticidal Activity of Doxycycline against the Common Bedbug</title><author>Pietri, Jose E ; Liang, Dangsheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a418t-d4fd6ae1f580328dc779b394703d77a05ef8baa3d28343e4cdeb3aab7f7f8e143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bedbugs - drug effects</topic><topic>Bedbugs - microbiology</topic><topic>Doxycycline - pharmacology</topic><topic>Experimental Therapeutics</topic><topic>Insecticides - pharmacology</topic><topic>Penicillins - pharmacology</topic><topic>Rifampin - pharmacology</topic><topic>Symbiosis - drug effects</topic><topic>Wolbachia - drug effects</topic><topic>Wolbachia - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pietri, Jose E</creatorcontrib><creatorcontrib>Liang, Dangsheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial agents and chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pietri, Jose E</au><au>Liang, Dangsheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insecticidal Activity of Doxycycline against the Common Bedbug</atitle><jtitle>Antimicrobial agents and chemotherapy</jtitle><stitle>Antimicrob Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2020-04-21</date><risdate>2020</risdate><volume>64</volume><issue>5</issue><issn>0066-4804</issn><eissn>1098-6596</eissn><abstract>There is an ongoing need for safe and effective anti-bedbug compounds. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Anti-Bacterial Agents - pharmacology Bedbugs - drug effects Bedbugs - microbiology Doxycycline - pharmacology Experimental Therapeutics Insecticides - pharmacology Penicillins - pharmacology Rifampin - pharmacology Symbiosis - drug effects Wolbachia - drug effects Wolbachia - metabolism |
| title | Insecticidal Activity of Doxycycline against the Common Bedbug |
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