Long-Term Compassionate Use of Cefiderocol To Treat Chronic Osteomyelitis Caused by Extensively Drug-Resistant Pseudomonas aeruginosa and Extended-Spectrum-β-Lactamase-Producing Klebsiella pneumoniae in a Pediatric Patient
We report a 15 year-old Nigerian adolescent male with chronic osteomyelitis caused by an extensively drug-resistant (XDR) strain of sequence type 773 (ST773) carrying and an extended spectrum β-lactamase (ESBL)-producing strain. The patient developed neurological side effects in the form of circumor...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2020-03, Vol.64 (4) |
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| container_title | Antimicrobial agents and chemotherapy |
| container_volume | 64 |
| creator | Alamarat, Zain I Babic, Jessica Tran, Truc T Wootton, Susan H Dinh, An Q Miller, William R Hanson, Blake Wanger, Audrey Gary, Joshua L Arias, Cesar A Pérez, Norma |
| description | We report a 15 year-old Nigerian adolescent male with chronic osteomyelitis caused by an extensively drug-resistant (XDR)
strain of sequence type 773 (ST773) carrying
and an extended spectrum β-lactamase (ESBL)-producing
strain. The patient developed neurological side effects in the form of circumoral paresthesia with polymyxin B and asymptomatic elevation of transaminases with aztreonam (used in combination with ceftazidime-avibactam). Cefiderocol treatment for 14 weeks plus bone implantation resulted in apparent cure and avoided amputation. |
| doi_str_mv | 10.1128/AAC.01872-19 |
| format | Article |
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strain of sequence type 773 (ST773) carrying
and an extended spectrum β-lactamase (ESBL)-producing
strain. The patient developed neurological side effects in the form of circumoral paresthesia with polymyxin B and asymptomatic elevation of transaminases with aztreonam (used in combination with ceftazidime-avibactam). Cefiderocol treatment for 14 weeks plus bone implantation resulted in apparent cure and avoided amputation.</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.01872-19</identifier><identifier>PMID: 31871075</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Adolescent ; Anti-Bacterial Agents - therapeutic use ; beta-Lactam Resistance - genetics ; beta-Lactamases - genetics ; Cefiderocol ; Cephalosporins - therapeutic use ; Challenging Clinical Case in Antimicrobial Resistance ; Comment On ; Compassionate Use Trials - methods ; Drug Resistance, Multiple, Bacterial - genetics ; Humans ; Klebsiella pneumoniae - drug effects ; Male ; Microbial Sensitivity Tests ; Nigeria ; Osteomyelitis - drug therapy ; Osteomyelitis - microbiology ; Pseudomonas aeruginosa - drug effects ; Surgical Wound Infection - drug therapy ; Surgical Wound Infection - microbiology</subject><ispartof>Antimicrobial agents and chemotherapy, 2020-03, Vol.64 (4)</ispartof><rights>Copyright © 2020 American Society for Microbiology.</rights><rights>Copyright © 2020 American Society for Microbiology. 2020 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a418t-828507ccaa37443bdac4bb9a5ee9740ddd39a1737581a1bc7fe7d87af15723583</citedby><cites>FETCH-LOGICAL-a418t-828507ccaa37443bdac4bb9a5ee9740ddd39a1737581a1bc7fe7d87af15723583</cites><orcidid>0000-0002-1518-2973 ; 0000-0003-2949-7818</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179260/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179260/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31871075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alamarat, Zain I</creatorcontrib><creatorcontrib>Babic, Jessica</creatorcontrib><creatorcontrib>Tran, Truc T</creatorcontrib><creatorcontrib>Wootton, Susan H</creatorcontrib><creatorcontrib>Dinh, An Q</creatorcontrib><creatorcontrib>Miller, William R</creatorcontrib><creatorcontrib>Hanson, Blake</creatorcontrib><creatorcontrib>Wanger, Audrey</creatorcontrib><creatorcontrib>Gary, Joshua L</creatorcontrib><creatorcontrib>Arias, Cesar A</creatorcontrib><creatorcontrib>Pérez, Norma</creatorcontrib><title>Long-Term Compassionate Use of Cefiderocol To Treat Chronic Osteomyelitis Caused by Extensively Drug-Resistant Pseudomonas aeruginosa and Extended-Spectrum-β-Lactamase-Producing Klebsiella pneumoniae in a Pediatric Patient</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>We report a 15 year-old Nigerian adolescent male with chronic osteomyelitis caused by an extensively drug-resistant (XDR)
strain of sequence type 773 (ST773) carrying
and an extended spectrum β-lactamase (ESBL)-producing
strain. The patient developed neurological side effects in the form of circumoral paresthesia with polymyxin B and asymptomatic elevation of transaminases with aztreonam (used in combination with ceftazidime-avibactam). Cefiderocol treatment for 14 weeks plus bone implantation resulted in apparent cure and avoided amputation.</description><subject>Adolescent</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>beta-Lactam Resistance - genetics</subject><subject>beta-Lactamases - genetics</subject><subject>Cefiderocol</subject><subject>Cephalosporins - therapeutic use</subject><subject>Challenging Clinical Case in Antimicrobial Resistance</subject><subject>Comment On</subject><subject>Compassionate Use Trials - methods</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>Humans</subject><subject>Klebsiella pneumoniae - drug effects</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Nigeria</subject><subject>Osteomyelitis - drug therapy</subject><subject>Osteomyelitis - microbiology</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Surgical Wound Infection - drug therapy</subject><subject>Surgical Wound Infection - microbiology</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ks9u1DAQxiMEokvhxhn5CBIudpzEyQVpFcofsVJXsD1bE3uydZXYW9up2NfiQXgFXoUsWyo4cLKs-c33zYy-LHvO2Rnnef1muWzPGK9lTnnzIFtw1tS0KpvqYbZgrKpoUbPiJHsS4zWb_2XDHmcnYuY5k-Ui-7nybks3GEbS-nEHMVrvICG5jEh8T1rsrcHgtR_IxpNNQEikvQreWU0uYkI_7nGwyUbSwhTRkG5Pzr8ldNHe4rAn78K0pV8w2pjAJbKOOBk_zh6RAM4163wEAs4cuwwa-nWHOoVppD--0xXoBCNEpOvgzaSt25LPA3bR4jAA2TmcZjELSKwjQNZoLKQwz7aGZNGlp9mjHoaIz-7e0-zy_fmm_UhXFx8-tcsVhYLXidZ5XTKpNYCQRSE6A7rougZKxEYWzBgjGuBSyLLmwDste5SmltDzUuairMVp9vaou5u6EY2erQMMahfsCGGvPFj1b8XZK7X1t0py2eQVmwVe3gkEfzNhTGq0UR-WdOinqHIhmBB5VRy8Xh9RHXyMAft7G87UIRNqzoT6nQnFmxl_dcQhjrm69lNw8yX-x774e4174T-BEb8ACGHGPQ</recordid><startdate>20200324</startdate><enddate>20200324</enddate><creator>Alamarat, Zain I</creator><creator>Babic, Jessica</creator><creator>Tran, Truc T</creator><creator>Wootton, Susan H</creator><creator>Dinh, An Q</creator><creator>Miller, William R</creator><creator>Hanson, Blake</creator><creator>Wanger, Audrey</creator><creator>Gary, Joshua L</creator><creator>Arias, Cesar A</creator><creator>Pérez, Norma</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1518-2973</orcidid><orcidid>https://orcid.org/0000-0003-2949-7818</orcidid></search><sort><creationdate>20200324</creationdate><title>Long-Term Compassionate Use of Cefiderocol To Treat Chronic Osteomyelitis Caused by Extensively Drug-Resistant Pseudomonas aeruginosa and Extended-Spectrum-β-Lactamase-Producing Klebsiella pneumoniae in a Pediatric Patient</title><author>Alamarat, Zain I ; 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strain of sequence type 773 (ST773) carrying
and an extended spectrum β-lactamase (ESBL)-producing
strain. The patient developed neurological side effects in the form of circumoral paresthesia with polymyxin B and asymptomatic elevation of transaminases with aztreonam (used in combination with ceftazidime-avibactam). Cefiderocol treatment for 14 weeks plus bone implantation resulted in apparent cure and avoided amputation.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>31871075</pmid><doi>10.1128/AAC.01872-19</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-1518-2973</orcidid><orcidid>https://orcid.org/0000-0003-2949-7818</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Antimicrobial agents and chemotherapy, 2020-03, Vol.64 (4) |
| issn | 0066-4804 1098-6596 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7179260 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adolescent Anti-Bacterial Agents - therapeutic use beta-Lactam Resistance - genetics beta-Lactamases - genetics Cefiderocol Cephalosporins - therapeutic use Challenging Clinical Case in Antimicrobial Resistance Comment On Compassionate Use Trials - methods Drug Resistance, Multiple, Bacterial - genetics Humans Klebsiella pneumoniae - drug effects Male Microbial Sensitivity Tests Nigeria Osteomyelitis - drug therapy Osteomyelitis - microbiology Pseudomonas aeruginosa - drug effects Surgical Wound Infection - drug therapy Surgical Wound Infection - microbiology |
| title | Long-Term Compassionate Use of Cefiderocol To Treat Chronic Osteomyelitis Caused by Extensively Drug-Resistant Pseudomonas aeruginosa and Extended-Spectrum-β-Lactamase-Producing Klebsiella pneumoniae in a Pediatric Patient |
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